# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4413926 | Binding | Displacement of [3H]-cytisine from alpha4beta2* nAChR in Wistar rat cerebral cortex membranes after 75 mins | Rattus norvegicus | 12 | ALA4411326 | cell membrane format | Scientific Literature | |
2. | ALA4413927 | Binding | Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometry | Rattus norvegicus | 12 | ALA4411326 | cell membrane format | Scientific Literature | |
3. | ALA4413929 | Binding | Selectivity ratio of Ki for alpha7* nAChR in rat brain P2 membranes to Ki for alpha4beta2* nAChR in Wistar rat cerebral cortex membranes | Rattus norvegicus | 11 | ALA4411326 | cell membrane format | Scientific Literature | |
4. | ALA4413930 | Binding | Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ levels in presence of PNU120596 by calcium flux assay | Homo sapiens | 5 | ALA4411326 | cell-based format | Scientific Literature | |
5. | ALA4413931 | Binding | Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay | Rattus norvegicus | 4 | ALA4411326 | cell-based format | Scientific Literature | |
6. | ALA4413932 | Binding | Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay | Homo sapiens | 4 | ALA4411326 | cell-based format | Scientific Literature | |
7. | ALA4413933 | Binding | Agonist activity at nAChR in human SH-SY5Y cells assessed as increase in intracellular Ca2+ levels measured every 2 secs for 3 mins by Fluo4AM-fluorescent dye based assay | Homo sapiens | 5 | ALA4411326 | cell-based format | Scientific Literature | |
8. | ALA4413934 | Binding | Agonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assay | Homo sapiens | 4 | ALA4411326 | cell-based format | Scientific Literature | |
9. | ALA4413935 | Binding | Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of nicotine-induced currents at 50 uM pretreated for 5 mins followed by nicotine addition after 4 to 5 days at -60 mV holding potential by patch clamp assay relative to control | Homo sapiens | 4 | ALA4411326 | cell-based format | Scientific Literature | |
10. | ALA4413936 | Binding | Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in intracellular Ca2+ levels at 0.025 to 250 uM by calcium flux assay relative to ACh | Rattus norvegicus | 2 | ALA4411326 | cell-based format | Scientific Literature | |
11. | ALA4413937 | Binding | Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes at 50 uM after 4 to 5 days at -60 mV holding potential by patch clamp assay relative to nicotine | Homo sapiens | 2 | ALA4411326 | cell-based format | Scientific Literature | |
12. | ALA4413938 | Binding | Agonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes at -60 mV holding potential by patch clamp assay relative to control | Homo sapiens | 3 | ALA4411326 | cell-based format | Scientific Literature |