| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4310452 | F | Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization preincubated for 2.3 mins followed by glutamate addition and measured after 1.7 mins by Fluo-4-AM dye based fluorescence assay | Rattus norvegicus | 37 | cell-based format | Scientific Literature | ||
| 2. | ALA4310453 | F | Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization at 30 uM preincubated for 2.3 mins followed by glutamate addition and measured after 1.7 mins by Fluo-4-AM dye based fluorescence assay relative to control | Rattus norvegicus | 32 | cell-based format | Scientific Literature | ||
| 3. | ALA4310454 | A | Fraction unbound in rat plasma after 4 hrs by equilibrium dialysis method | Rattus norvegicus | 10 | cell-free format | Scientific Literature | ||
| 4. | ALA4310455 | A | Fraction unbound in human plasma after 4 hrs by equilibrium dialysis method | Homo sapiens | 10 | cell-free format | Scientific Literature | ||
| 5. | ALA4310456 | A | Fraction unbound in rat brain | Rattus norvegicus | 10 | tissue-based format | Scientific Literature | ||
| 6. | ALA4310457 | A | Brain to plasma partition coefficient, Kp of the compound in Sprague-Dawley rat at 0.2 mg/kg, iv administered as cassette dose by LC-MS/MS analysis | Rattus norvegicus | 14 | organism-based format | Scientific Literature | ||
| 7. | ALA4310458 | A | Unbound brain to plasma ratio in Sprague-Dawley rat at 0.2 mg/kg, iv administered as cassette dose by LC-MS/MS analysis | Rattus norvegicus | 14 | organism-based format | Scientific Literature |
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