| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4323334 | B | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.05 uM incubated for 2 mins by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 2. | ALA4323335 | B | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.1 uM incubated for 2 mins by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 3. | ALA4323336 | B | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.5 uM incubated for 2 mins by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA4323354 | B | Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 5. | ALA4323355 | A | Passive membrane permeability by LC-MS/MS analysis based PAMPA | 23 | assay format | Scientific Literature | |||
| 6. | ALA4323382 | A | Cmax in human at 50 mg, iv | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA4323383 | A | Unbound Cmax in human at 50 mg, iv | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4323384 | A | Unbound maximal portal vein concentration of in human at 50 mg, iv | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 9. | ALA4323385 | A | Ratio of unbound Cmax in human at 50 mg, iv to inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4323386 | A | Ratio of unbound maximal portal vein concentration in human at 50 mg, iv to inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4323387 | A | Cmax in human at 50 mg, po | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA4323388 | A | Unbound Cmax in human at 50 mg, po | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA4323389 | A | Unbound maximal portal vein concentration of in human at 50 mg, po | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA4323390 | A | Ratio of unbound Cmax in human at 50 mg, po to inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4323391 | A | Ratio of unbound maximal portal vein concentration in human at 50 mg, po to inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis | Homo sapiens | 1 | organism-based format | Scientific Literature |
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