| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4330318 | Functional | Antiviral activity against Ebolavirus H. sapiens-wt/1995/Kikwit-9510621 infected in human HeLa cells assessed as inhibition of viral infection pretreated for 2 hrs followed by viral infection and measured after 48 hrs by EboV GP immunostaining based high content imaging analysis | Ebolavirus | 19 | ALA4330057 | organism-based format | Scientific Literature | |
| 2. | ALA4330321 | ADME | Cytotoxicity against human HeLa cells after 2 hrs by high content imaging analysis | Homo sapiens | 13 | ALA4330057 | cell-based format | Scientific Literature | |
| 3. | ALA4330323 | Toxicity | Selectivity index, ratio of CC50 for human HeLa cells to EC50 for Ebolavirus H. sapiens-wt/1995/Kikwit-9510621 infected in human HeLa cells | 12 | ALA4330057 | cell-based format | Scientific Literature | ||
| 4. | ALA4330325 | ADME | Stability in plasma (unknown origin) after 1 hr at 37 degC | Not specified | 3 | ALA4330057 | cell-free format | Scientific Literature | |
| 5. | ALA4330326 | Physicochemical | Solubility of the compound in pH 7.4 buffer by laser nephelometric method | 3 | ALA4330057 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4330327 | ADME | Inhibition of CYP3A4 (unknown origin) using 7-benzyloxyquinoline as substrate | Homo sapiens | 3 | ALA4330057 | single protein format | Scientific Literature | |
| 7. | ALA4330328 | ADME | Inhibition of CYP3A4 (unknown origin) using dibenzylfluorescein as substrate | Homo sapiens | 3 | ALA4330057 | single protein format | Scientific Literature | |
| 8. | ALA4330329 | ADME | Inhibition of CYP3A4 (unknown origin) using 7-benzyloxy-4-trifluoromethylcoumarin as substrate | Homo sapiens | 3 | ALA4330057 | single protein format | Scientific Literature | |
| 9. | ALA4330330 | ADME | Inhibition of CYP2D6 (unknown origin) using 3-(2-(N, N-Diethyl-N-methylamino)ethyl)-7-Methoxy-4-Methylcoumarin as substrate | Homo sapiens | 3 | ALA4330057 | single protein format | Scientific Literature | |
| 10. | ALA4330331 | ADME | Inhibition of CYP2C19 (unknown origin) using CEC as substrate | Homo sapiens | 3 | ALA4330057 | single protein format | Scientific Literature | |
| 11. | ALA4330332 | ADME | Clearance in mouse liver microsomes after 1 hr | Mus musculus | 3 | ALA4330057 | microsome format | Scientific Literature | |
| 12. | ALA4330333 | ADME | Clearance in human liver microsomes after 1 hr | Homo sapiens | 3 | ALA4330057 | microsome format | Scientific Literature | |
| 13. | ALA4330334 | ADME | Half life in mouse liver microsomes | Mus musculus | 3 | ALA4330057 | microsome format | Scientific Literature | |
| 14. | ALA4330335 | ADME | Half life in human liver microsomes | Homo sapiens | 3 | ALA4330057 | microsome format | Scientific Literature | |
| 15. | ALA4330373 | Physicochemical | Solubility of the compound in deionized water | 3 | ALA4330057 | small-molecule physicochemical format | Scientific Literature |
The page will load shortly, Thanks for your patience!