# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4366984 | Functional | Antiproliferative activity against human A375 cells after 72 hrs by MTT assay | Homo sapiens | 28 | ALA4364286 | cell-based format | Scientific Literature | |
2. | ALA4366985 | Functional | Antiproliferative activity against human M14 cells after 72 hrs by MTT assay | Homo sapiens | 28 | ALA4364286 | cell-based format | Scientific Literature | |
3. | ALA4366986 | Functional | Antiproliferative activity against human WM164 cells after 72 hrs by MTT assay | Homo sapiens | 28 | ALA4364286 | cell-based format | Scientific Literature | |
4. | ALA4366987 | Binding | Inhibition of bovine brain tubulin polymerization at 10 uM measured at time interval of 1 mins for 20 mins by spectrophotometric analysis | Bos taurus | 2 | ALA4364286 | assay format | Scientific Literature | |
5. | ALA4366988 | Binding | Disruption of microtubule network in human WM164 cells assessed as microtubule fragmentation at 100 nM after 18 hrs by DAPI staining based fluorescence confocal microscopic method | Homo sapiens | 2 | ALA4364286 | cell-based format | Scientific Literature | |
6. | ALA4366989 | Binding | Disruption of microtubule network in human WM164 cells assessed as microtubule disassembly at 100 nM after 18 hrs by DAPI staining based fluorescence confocal microscopic method | Homo sapiens | 2 | ALA4364286 | cell-based format | Scientific Literature | |
7. | ALA4366990 | Functional | Inhibition of anchorage-dependent colony formation in human A375 cells assessed as decrease in colony number at 5 nM after 12 days by crystal violet-staining based assay relative to control | Homo sapiens | 3 | ALA4364286 | cell-based format | Scientific Literature | |
8. | ALA4366991 | Functional | Antimigratory activity in human A375 cells assessed as wound closure at 5 nM after 22 hrs by scratch migration assay (Rvb = 60.7 +/- 3.5%) | Homo sapiens | 3 | ALA4364286 | cell-based format | Scientific Literature | |
9. | ALA4366992 | Functional | Antimigratory activity in human A375 cells assessed as wound closure at 25 nM after 22 hrs by scratch migration assay (Rvb = 60.7 +/- 3.5%) | Homo sapiens | 3 | ALA4364286 | cell-based format | Scientific Literature | |
10. | ALA4366993 | Functional | Antimigratory activity in human RPMI7951 cells assessed as wound closure at 25 nM after 18 hrs by scratch migration assay (Rvb = 71.8 +/- 1.8%) | Homo sapiens | 3 | ALA4364286 | cell-based format | Scientific Literature | |
11. | ALA4366994 | ADME | Half-life in CD-1 mouse liver microsomes in presence of NADPH regenerating system measured up to 4 hrs by UPLC-MS analysis | Mus musculus | 5 | ALA4364286 | microsome format | Scientific Literature | |
12. | ALA4366995 | ADME | Intrinsic clearance in CD-1 mouse liver microsomes in presence of NADPH regenerating system measured up to 4 hrs by UPLC-MS analysis | Mus musculus | 5 | ALA4364286 | microsome format | Scientific Literature | |
13. | ALA4366996 | ADME | Half-life in rat liver microsomes pre-incubated for 15 mins followed by addition of NADPH regenerating system by LC-MS analysis | Rattus norvegicus | 5 | ALA4364286 | microsome format | Scientific Literature | |
14. | ALA4366997 | ADME | Intrinsic clearance in rat liver microsomes pre-incubated for 15 mins followed by addition of NADPH regenerating system by LC-MS analysis | Rattus norvegicus | 5 | ALA4364286 | microsome format | Scientific Literature | |
15. | ALA4366998 | ADME | Half-life in human liver microsomes in presence of NADPH regenerating system | Homo sapiens | 5 | ALA4364286 | microsome format | Scientific Literature | |
16. | ALA4366999 | ADME | Intrinsic clearance in human liver microsomes in presence of NADPH regenerating system | Homo sapiens | 5 | ALA4364286 | microsome format | Scientific Literature | |
17. | ALA4367023 | Functional | Antiproliferative activity against human PC3 cells | Homo sapiens | 5 | ALA4364286 | cell-based format | Scientific Literature | |
18. | ALA4367024 | Functional | Antiproliferative activity against human PC3-TxR cells | Homo sapiens | 5 | ALA4364286 | cell-based format | Scientific Literature | |
19. | ALA4367025 | Functional | Resistance index, ratio of IC50 for human PC3-TxR cells to IC50 for human PC3 cells | Homo sapiens | 5 | ALA4364286 | assay format | Scientific Literature | |
20. | ALA4367026 | Functional | Antiproliferative activity against human DU145 cells | Homo sapiens | 5 | ALA4364286 | cell-based format | Scientific Literature |