| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4395918 | B | Inhibition of human topoisomerase 2alpha using supercoiled pNO1 plasmid as substrate after 30 mins by HTS assay | Homo sapiens | 39 | single protein format | Scientific Literature | ||
| 2. | ALA4395919 | B | Inhibition of human topoisomerase-2alpha mediated decatenation at 3.9 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 3. | ALA4395920 | B | Inhibition of human topoisomerase-2alpha mediated decatenation at 31.5 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 4. | ALA4395921 | B | Inhibition of human topoisomerase-2alpha mediated decatenation at 125 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 5. | ALA4395922 | B | Inhibition of human topoisomerase-2alpha mediated decatenation at 500 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 6. | ALA4395923 | B | Inhibition of human topoisomerase-2beta mediated decatenation at 3.9 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 7. | ALA4395924 | B | Inhibition of human topoisomerase-2beta mediated decatenation at 31.5 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 8. | ALA4395925 | B | Inhibition of human topoisomerase-2beta mediated decatenation at 125 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 9. | ALA4395926 | B | Inhibition of human topoisomerase-2beta mediated decatenation at 500 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 10. | ALA4395927 | A | Poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 3.9 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 8.11 %) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 11. | ALA4395928 | A | Poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 31.5 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 8.11 %) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA4395929 | A | Poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 125 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 8.11 %) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA4395930 | A | Poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 500 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 8.11 %) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 14. | ALA4395931 | B | Inhibition of etoposide induced poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 3.9 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 35.56 microM/min) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 15. | ALA4395932 | B | Inhibition of etoposide induced poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 31.5 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 35.56 microM/min) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 16. | ALA4395933 | B | Inhibition of etoposide induced poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 125 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 35.56 microM/min) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 17. | ALA4395934 | B | Inhibition of etoposide induced poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 500 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 35.56 microM/min) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 18. | ALA4395936 | B | Inhibition of human topoisomerase-2alpha assessed as rate of ATP hydrolysis at 10 uM using linear pBR322 DNA as substrate measured up to 30 mins in presence of 2 mM ATP by pyruvate kinase/lactate dehydrogenase enzyme coupled assay (Rvb = 2.810 microM/min) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA4395937 | B | Inhibition of human topoisomerase-2alpha assessed as rate of ATP hydrolysis at 10 uM using linear pBR322 DNA as substrate measured up to 30 mins in presence of 1 mM ATP by pyruvate kinase/lactate dehydrogenase enzyme coupled assay (Rvb = 2.488 to 2.810 microM/min) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4395938 | B | Inhibition of human topoisomerase-2alpha assessed as rate of ATP hydrolysis at 10 uM using linear pBR322 DNA as substrate measured up to 30 mins in presence of 0.75 mM ATP by pyruvate kinase/lactate dehydrogenase enzyme coupled assay (Rvb = 2.810 microM/min) | Homo sapiens | 1 | single protein format | Scientific Literature |
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