# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4403880 | Binding | Displacement of [3H]-diprenorphine from human MOR expressed in CHO cell membranes incubated for 1 hr by scintillation counting method | Homo sapiens | 5 | ALA4402550 | cell-based format | Scientific Literature | |
2. | ALA4403881 | Binding | Displacement of [3H]-diprenorphine from human DOR expressed in CHO cell membranes incubated for 1 hr by scintillation counting method | Homo sapiens | 5 | ALA4402550 | cell-based format | Scientific Literature | |
3. | ALA4403882 | Binding | Displacement of [3H]-diprenorphine from human KOR expressed in CHO cell membranes incubated for 1 hr by scintillation counting method | Homo sapiens | 5 | ALA4402550 | cell-based format | Scientific Literature | |
4. | ALA4403883 | Binding | Selectivity index, ratio of Ki for displacement of [3H]-diprenorphine from human DOR expressed in CHO cell membranes to KI for displacement of [3H]-diprenorphine from human MOR expressed in CHO cell membranes | Homo sapiens | 4 | ALA4402550 | cell-based format | Scientific Literature | |
5. | ALA4403884 | Binding | Selectivity index, ratio of Ki for displacement of [3H]-diprenorphine from human KOR expressed in CHO cell membranes to KI for displacement of [3H]-diprenorphine from human MOR expressed in CHO cell membranes | Homo sapiens | 4 | ALA4402550 | cell-based format | Scientific Literature | |
6. | ALA4403885 | Binding | Selectivity index, ratio of Ki for displacement of [3H]-diprenorphine from human KOR expressed in CHO cell membranes to KI for displacement of [3H]-diprenorphine from human DOR expressed in CHO cell membranes | Homo sapiens | 4 | ALA4402550 | cell-based format | Scientific Literature | |
7. | ALA4403886 | Functional | Agonist activity at human MOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assay | Homo sapiens | 5 | ALA4402550 | cell-based format | Scientific Literature | |
8. | ALA4403887 | Functional | Agonist activity at human MOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assay relative to DAMGO | Homo sapiens | 4 | ALA4402550 | cell-based format | Scientific Literature | |
9. | ALA4403888 | Functional | Agonist activity at human DOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assay | Homo sapiens | 5 | ALA4402550 | cell-based format | Scientific Literature | |
10. | ALA4403889 | Functional | Agonist activity at human DOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assay relative to SNC80 | Homo sapiens | 4 | ALA4402550 | cell-based format | Scientific Literature | |
11. | ALA4403890 | Functional | Antagonist activity at human DOR expressed in CHO cell membranes assessed as reduction in SNC80-induced response incubated for 1 hr by [35S]-GTPgammaS coupling assay | Homo sapiens | 3 | ALA4402550 | cell-based format | Scientific Literature | |
12. | ALA4403891 | Functional | Antagonist activity at human DOR expressed in CHO cell membranes assessed as reduction in SNC80-induced response incubated for 1 hr by [35S]-GTPgammaS coupling assay relative to naloxone | Homo sapiens | 2 | ALA4402550 | cell-based format | Scientific Literature | |
13. | ALA4403892 | Functional | Agonist activity at human KOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assay | Homo sapiens | 5 | ALA4402550 | cell-based format | Scientific Literature | |
14. | ALA4403893 | Functional | Agonist activity at human KOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assay relative to U50,488 | Homo sapiens | 4 | ALA4402550 | cell-based format | Scientific Literature | |
15. | ALA4403897 | Functional | Antinociceptive activity in CD1 mouse assessed as reduction in thermal nociception at 1.5 umol/kg, iv dosed 15 mins before test and measured after 15 to 120 mins post compound dose by hot plate test | Mus musculus | 7 | ALA4402550 | organism-based format | Scientific Literature | |
16. | ALA4403900 | Functional | Antinociceptive activity in CD1 mouse assessed as reduction in nociception response during early phase at 0.15 umol,sc dosed 15 mins before test by formalin test | Mus musculus | 6 | ALA4402550 | organism-based format | Scientific Literature | |
17. | ALA4403901 | Functional | Antinociceptive activity in CD1 mouse assessed as reduction in nociception response during late phase at 0.15 umol,sc dosed 15 mins before test by formalin test | Mus musculus | 6 | ALA4402550 | organism-based format | Scientific Literature |