| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4377282 | Binding | Inhibition of recombinant human N-terminal His6-tagged SPIN2B (45 to 258 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 1 | ALA4376809 | cell-based format | Scientific Literature | |
| 2. | ALA4377289 | Binding | Inhibition of FL-H3K4me3 binding to recombinant human C-terminal His6-tagged SPIN1 (49 to 262 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by fluorescence polarization displacement assay | Homo sapiens | 5 | ALA4376809 | cell-based format | Scientific Literature | |
| 3. | ALA4377290 | Binding | Inhibition of biotin-H3(1-23)K4me3 binding to recombinant human C-terminal His6-tagged SPIN1 (49 to 262 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 90 mins by AlphaLISA assay | Homo sapiens | 5 | ALA4376809 | cell-based format | Scientific Literature | |
| 4. | ALA4377291 | Binding | Inhibition of human G9a catalytic domain/GLP catalytic domain in presence of SAM assessed as dissociation constant by isothermal calorimetry assay | Homo sapiens | 2 | ALA4376809 | protein format | Scientific Literature | |
| 5. | ALA4377292 | Binding | Inhibition of recombinant human C-terminal His6-tagged SPIN1 (49 to 262 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 3 | ALA4376809 | cell-based format | Scientific Literature | |
| 6. | ALA4377293 | Binding | Inhibition of recombinant human N-terminal His6-tagged SPIN3 (27 to 258 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 1 | ALA4376809 | cell-based format | Scientific Literature | |
| 7. | ALA4377294 | Binding | Inhibition of recombinant human N-terminal His6-tagged SPIN4 (36 to 249 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 1 | ALA4376809 | cell-based format | Scientific Literature | |
| 8. | ALA4377295 | Binding | Inhibition of C-terminal Halo Tag-histone H3.3/N-terminal Nano Luciferase-fused full length SPIN1 (unknown origin) transfected in human U2OS cells assessed as reduction in SPIN1 and histone H3 interaction incubated for 24 hrs by NanoBRET assay | Homo sapiens | 2 | ALA4376809 | cell-based format | Scientific Literature | |
| 9. | ALA4377296 | ADME | Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability up to 30 uM incubated for 6 days by resazurin dye based fluorescence assay | Mus musculus | 1 | ALA4376809 | cell-based format | Scientific Literature | |
| 10. | ALA4377297 | ADME | Cytotoxicity against human 293T cells assessed as reduction in cell viability up to 30 uM incubated for 6 days by resazurin dye based fluorescence assay | Homo sapiens | 1 | ALA4376809 | cell-based format | Scientific Literature | |
| 11. | ALA4377298 | ADME | Cytotoxicity against human HFF1 cells assessed as reduction in cell viability up to 30 uM incubated for 6 days by resazurin dye based fluorescence assay | Homo sapiens | 1 | ALA4376809 | cell-based format | Scientific Literature | |
| 12. | ALA4377299 | Binding | Inhibition of human G9a up to 50 uM using Biot-H3 (1-25) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4376809 | single protein format | Scientific Literature | |
| 13. | ALA4377300 | Binding | Inhibition of human GLP up to 50 uM using Biot-H3 (1-25) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4376809 | single protein format | Scientific Literature | |
| 14. | ALA4377301 | Binding | Inhibition of human SETDB1 up to 50 uM using Biot-H3 (1-25) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4376809 | single protein format | Scientific Literature | |
| 15. | ALA4377302 | Binding | Inhibition of human SUV39H1 up to 50 uM using Biot-H3 (1-25) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4376809 | single protein format | Scientific Literature | |
| 16. | ALA4377303 | Binding | Inhibition of human SUV39H2 up to 50 uM using Biot-H3 (1-25) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4376809 | single protein format | Scientific Literature | |
| 17. | ALA4377304 | Binding | Inhibition of human PRDM9 up to 50 uM using Biot-H3 (1-25) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4376809 | single protein format | Scientific Literature | |
| 18. | ALA4377305 | Binding | Inhibition of human MLL1/RBBP5/WDR5 trimeric complex up to 50 uM using Biot-H3 (1-25) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4376809 | assay format | Scientific Literature | |
| 19. | ALA4377306 | Binding | Inhibition of human MLL3/ASH2L/RBBP5/WDR5/DPY30 pentameric complex up to 50 uM using Biot-H3 (1-25) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4376809 | assay format | Scientific Literature | |
| 20. | ALA4377307 | Binding | Inhibition of human SETD7 up to 50 uM using Biot-H3 (1-25) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4376809 | single protein format | Scientific Literature |
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