# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4393072 | Functional | Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incubated for 142 secs prior to glutamate addition for 120 secs followed by L-AP4 addition and measured after 40 secs by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 39 | ALA4392832 | cell-based format | Scientific Literature | |
2. | ALA4393073 | Functional | Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as minimum L-AP4 response by measuring reduction in calcium mobilization incubated for 142 secs prior to glutamate addition for 120 secs followed by L-AP4 addition and measured after 40 secs by Fluo-4 AM dye based fluorescence assay relative to L-AP4 alone | Rattus norvegicus | 22 | ALA4392832 | cell-based format | Scientific Literature | |
3. | ALA5106321 | Functional | Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mobilization assay | Rattus norvegicus | 23 | ALA5104167 | cell-based format | Scientific Literature | |
4. | ALA5106322 | Functional | Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mobilization assay relative to control | Rattus norvegicus | 22 | ALA5104167 | cell-based format | Scientific Literature | |
5. | ALA5106324 | Binding | Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay relative to control | Homo sapiens | 22 | ALA5104167 | assay format | Scientific Literature |