# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4422002 | Binding | Binding affinity to nuclear export signal of topoisomerase 2alpha in human NCI-H929 cells assessed as potentiation of doxorubicin-induced apoptosis by measuring increase in cleaved caspase-3 levels at 25 uM pre-incubated for 20 hrs followed by addition of doxorubicin for 4 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
2. | ALA4422003 | Binding | Binding affinity to nuclear export signal of topoisomerase 2alpha in human RPMI8226 cells assessed as potentiation of doxorubicin-induced apoptosis by measuring increase in cleaved caspase-3 levels at 25 uM pre-incubated for 20 hrs followed by addition of doxorubicin for 4 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
3. | ALA4422004 | Binding | Binding affinity to nuclear export signal of topoisomerase 2alpha in human U266 cells assessed as potentiation of doxorubicin-induced apoptosis by measuring increase in cleaved caspase-3 levels at 25 uM pre-incubated for 20 hrs followed by addition of doxorubicin for 4 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
4. | ALA4422005 | Functional | Induction of apoptosis in human NCI-H929 cells assessed as increase in cleaved caspase-3 levels at 25 uM incubated for 20 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
5. | ALA4422006 | Functional | Induction of apoptosis in human RPMI8226 cells assessed as increase in cleaved caspase-3 levels at 25 uM incubated for 20 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
6. | ALA4422007 | Functional | Induction of apoptosis in human U266 cells assessed as increase in cleaved caspase-3 levels at 25 uM incubated for 20 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data |