| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4479676 | Binding | Inhibition of full-length recombinant human GST-tagged MARK3 expressed in baculovirus expression system using biotinylated-Cdc25C peptide substrate measured after 2 hrs by HTRF assay | Homo sapiens | 27 | ALA4477252 | assay format | Scientific Literature | |
| 2. | ALA4479677 | Binding | Inhibition of MARK4 in mouse cortical neurons assessed as inhibition of okadaic acid-induced tau phosphorylation at S262 residue preincubated for 15 mins followed okadaic acid challenge for 1.5 hrs by immunostaining method | Mus musculus | 4 | ALA4477252 | single protein format | Scientific Literature | |
| 3. | ALA4479678 | ADME | Clearance in Sprague-Dawley rat at 1 mL/kg, iv administered through catheter measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4477252 | organism-based format | Scientific Literature | |
| 4. | ALA4479680 | ADME | Volume of distribution in Sprague-Dawley rat at 1 mL/kg, iv administered through catheter or 5 mL/kg administered through gastric gavage measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4477252 | organism-based format | Scientific Literature | |
| 5. | ALA4479681 | ADME | Substrate activity at human MDR1 expressed in LLC-PK1 cells assessed as efflux ratio of permeability across basolateral to apical over apical to basolateral side at 5 uM | Homo sapiens | 7 | ALA4477252 | cell-based format | Scientific Literature | |
| 6. | ALA4479683 | ADME | Apparent permeability from basolateral to apical side over apical to basolateral side in pig LLC-PK1 cells expressing MDR1 (unknown origin) at 5 uM measured after 3 hrs | Sus scrofa | 4 | ALA4477252 | cell-based format | Scientific Literature | |
| 7. | ALA4479684 | Physicochemical | Solubility of the compound at pH 7 | 15 | ALA4477252 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4479685 | ADME | Half life in Sprague-Dawley rat at 1 mL/kg, iv administered through catheter measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4477252 | organism-based format | Scientific Literature | |
| 9. | ALA4479686 | ADME | Clearance in Beagle dog at 0.5 mL/kg, iv administered through catheter measured after 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA4477252 | organism-based format | Scientific Literature | |
| 10. | ALA4479687 | ADME | Volume of distribution in Beagle dog at 0.5 mL/kg, iv administered through catheter or 5 mL/kg, administered through gastric gavage measured after 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA4477252 | organism-based format | Scientific Literature | |
| 11. | ALA4479688 | ADME | Half life in Beagle dog at 0.5 mL/kg, iv administered through catheter or 5 mL/kg, administered through gastric gavage measured after 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA4477252 | organism-based format | Scientific Literature | |
| 12. | ALA4479689 | Binding | Inhibition of full-length human His-tagged ABL1 expressed in baculovirus expression system by Z'-LYTE assay | Homo sapiens | 4 | ALA4477252 | assay format | Scientific Literature | |
| 13. | ALA4479690 | Binding | Inhibition of full-length recombinant human His-tagged ADRBK1 expressed in baculovirus expression system by Z'-LYTE assay | Homo sapiens | 4 | ALA4477252 | assay format | Scientific Literature | |
| 14. | ALA4479691 | Binding | Inhibition of full-length recombinant human His-tagged AKT1-alpha expressed in baculovirus expression system by Z'-LYTE assay | Homo sapiens | 4 | ALA4477252 | assay format | Scientific Literature | |
| 15. | ALA4479692 | Binding | Inhibition of full-length recombinant human His-tagged AKT2 expressed in baculovirus expression system by Z'-LYTE assay | Homo sapiens | 4 | ALA4477252 | assay format | Scientific Literature | |
| 16. | ALA4479693 | Binding | Inhibition of full-length recombinant human His-tagged AKT3 expressed in baculovirus expression system by Z'-LYTE assay | Homo sapiens | 4 | ALA4477252 | assay format | Scientific Literature | |
| 17. | ALA4479694 | Binding | Inhibition of recombinant human GST-tagged ALK4 catalytic domain expressed in baculovirus expression system by Z'-LYTE assay | Homo sapiens | 4 | ALA4477252 | assay format | Scientific Literature | |
| 18. | ALA4479695 | Binding | Inhibition of full-length recombinant human GST and His-tagged AMPK alpha1/beta1/gamma1 expressed in baculovirus expression system by LanthaScreen assay | Homo sapiens | 4 | ALA4477252 | assay format | Scientific Literature | |
| 19. | ALA4479696 | Binding | Inhibition of full-length recombinant human GST and His-tagged AMPK alpha2/beta1/gamma1 expressed in baculovirus expression system by LanthaScreen assay | Homo sapiens | 4 | ALA4477252 | assay format | Scientific Literature | |
| 20. | ALA4479697 | Binding | Inhibition of full-length recombinant human His-tagged AURKB expressed in baculovirus expression system by LanthaScreen assay | Homo sapiens | 4 | ALA4477252 | assay format | Scientific Literature |
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