# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4400641 | Binding | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 16 | ALA4400508 | subcellular format | Scientific Literature | |
2. | ALA4400642 | Binding | Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 16 | ALA4400508 | assay format | Scientific Literature | |
3. | ALA4400643 | Binding | Selectivity factor, ratio of IC50 for human placental cytosolic fraction 17beta-HSD1 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 16 | ALA4400508 | subcellular format | Scientific Literature | |
4. | ALA4400644 | Binding | Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Mus musculus | 14 | ALA4400508 | tissue-based format | Scientific Literature | |
5. | ALA4400646 | Binding | Inhibition of recombinant mouse 17beta-HSD1 expressed in HEK293 cells at 500 nM using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis relative to control | Mus musculus | 14 | ALA4400508 | cell-based format | Scientific Literature | |
6. | ALA4400649 | ADME | Cytotoxicity against HEK293 cells assessed as reduction in cell viability over 66 hrs by MTT assay relative to control | Homo sapiens | 2 | ALA4400508 | cell-based format | Scientific Literature | |
7. | ALA4400650 | Unassigned | Selectivity index, ratio of cytotoxicity against HEK293 cells to IC50 for human placental microsomal fraction 17beta-HSD2 | 2 | ALA4400508 | cell-based format | Scientific Literature | ||
8. | ALA4400655 | Binding | Displacement of [3H]-E2 from human recombinant ERalpha after 16 to 20 hrs in presence of 1000 fold excess of N-{3-[5-(2,4,5-Trifluoro-3-hydroxybenzoyl)thiophen-2-yl]-phenyl}-2-trifluoromethoxybenzenesulfonamide by liquid scintillation counting analysis relative to control | Homo sapiens | 1 | ALA4400508 | single protein format | Scientific Literature | |
9. | ALA4400656 | Binding | Displacement of [3H]-E2 from human recombinant ERbeta after 16 to 20 hrs in presence of 1000 fold excess of N-{3-[5-(2,4,5-Trifluoro-3-hydroxybenzoyl)thiophen-2-yl]-phenyl}-2-trifluoromethoxybenzenesulfonamide by liquid scintillation counting analysis relative to control | Homo sapiens | 1 | ALA4400508 | single protein format | Scientific Literature | |
10. | ALA4400659 | ADME | Half life in human liver S9 fraction in presence of NADPH, UDPGA, PAPS | Homo sapiens | 16 | ALA4400508 | subcellular format | Scientific Literature |