# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4397084 | A | Activation of non-specific gene expression in HEK293- FlpIn-FM cells harboring LTR driven CBG reporter co-expressing CMV driven CBR reporter assessed as CMV driven gene expression at 40 uM incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay | Homo sapiens | 6 | ALA4396867 | cell-based format | Scientific Literature | |
2. | ALA4397085 | A | Activation of non-specific gene expression in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as CMV driven gene expression incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay | Homo sapiens | 102 | ALA4396867 | cell-based format | Scientific Literature | |
3. | ALA4397086 | B | Activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as LTR-driven gene expression incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay | Human immunodeficiency virus 1 | 102 | ALA4396867 | cell-based format | Scientific Literature | |
4. | ALA4397095 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay | Homo sapiens | 14 | ALA4396867 | cell-based format | Scientific Literature | |
5. | ALA4397096 | A | Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay | Homo sapiens | 14 | ALA4396867 | cell-based format | Scientific Literature | |
6. | ALA4397099 | B | Activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as maximum LTR activity at 1.3 uM incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay relative to control | Human immunodeficiency virus 1 | 3 | ALA4396867 | cell-based format | Scientific Literature | |
7. | ALA4397105 | B | Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as LTR-driven gene expression incubated for 48 hr by FACSCalibur flow cytometry | Human immunodeficiency virus 1 | 14 | ALA4396867 | cell-based format | Scientific Literature | |
8. | ALA4397106 | A | Activation of non-specific gene expression in human J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as CMV driven gene expression incubated for 48 hr by FACSCalibur flow cytometry | Homo sapiens | 14 | ALA4396867 | cell-based format | Scientific Literature | |
9. | ALA4397135 | T | Selectivity ratio of EC50 for activation of non-specific gene expression in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as CMV driven gene expression to EC50 for activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as LTR-driven gene expression | 13 | ALA4396867 | cell-based format | Scientific Literature | ||
10. | ALA4397136 | B | Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as maximum LTR activity at 20 uM incubated for 48 hr by FACSCalibur flow cytometry relative to control | Human immunodeficiency virus 1 | 6 | ALA4396867 | cell-based format | Scientific Literature | |
11. | ALA4768755 | F | Antiviral activity against HIV-1 infected in FlpIn-HEK293 cells assessed as maximal activation of long terminal repeat driven gene expression at 1.3 uM incubated for 48 hrs by luciferase based cellular assay relative to control | Human immunodeficiency virus 1 | 1 | ALA4765284 | organism-based format | Scientific Literature | |
12. | ALA4768763 | F | Antiviral activity against HIV-1 infected in J-Lat 10.6 cells assessed as maximal activation of long terminal repeat driven gene expression incubated for 48 hrs by green fluorescent protein based cellular assay | Human immunodeficiency virus 1 | 11 | ALA4765284 | organism-based format | Scientific Literature | |
13. | ALA4768769 | A | Cytotoxicity against human HepG2 cells assessed as growth incubation incubated for 48 hrs by cell titer glo assay | Homo sapiens | 11 | ALA4765284 | cell-based format | Scientific Literature | |
14. | ALA4768770 | F | Antiviral activity against HIV-1 infected in J-Lat 10.6 cells assessed as maximal activation of long terminal repeat driven gene expression at 20 uM incubated for 48 hrs by green fluorescent protein based cellular assay relative to control | Human immunodeficiency virus 1 | 1 | ALA4765284 | organism-based format | Scientific Literature |