| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4403861 | Binding | Inhibition of wild type human GST-tagged LRRK2 (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP formation at 10 uM using LRRKtide as substrate measured after 1 hr in presence of ATP by Adapta assay relative to control | Homo sapiens | 19 | ALA4402549 | assay format | Scientific Literature | |
| 2. | ALA4403862 | Binding | Inhibition of wild type human GST-tagged LRRK2 (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP formation using LRRKtide as substrate measured after 1 hr in presence of ATP by Adapta assay | Homo sapiens | 13 | ALA4402549 | assay format | Scientific Literature | |
| 3. | ALA4403863 | Binding | Inhibition of human GST-tagged LRRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP formation at 10 uM using LRRKtide as substrate measured after 1 hr in presence of ATP by Adapta assay relative to control | Homo sapiens | 12 | ALA4402549 | assay format | Scientific Literature | |
| 4. | ALA4403864 | Binding | Inhibition of human GST-tagged LRRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP formation using LRRKtide as substrate measured after 1 hr in presence of ATP by Adapta assay | Homo sapiens | 12 | ALA4402549 | assay format | Scientific Literature | |
| 5. | ALA4403865 | ADME | Permeability of compound in PBS/EtOH buffer (7:3) at 100 ul and pH 7.4 after 2 hrs and 30 mins by UV plate reader based PAMPA-BBB assay | 11 | ALA4402549 | assay format | Scientific Literature |
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