# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4478408 | B | Inhibition of VGCC in human SHSY-5Y cells assessed as reduction of K+-evoked cytosolic ca2+ at 1 uM incubated for 10 mins prior to KCl addition by Fluo-4-AM probe-based fluorescence analysis | Homo sapiens | 25 | ALA4477210 | cell-based format | Scientific Literature | |
2. | ALA4478410 | B | Suppression of okadaic acid-induced inhibition of PP1/PP2A in human SHSY-5Y cells at 0.1 uM using pNPP as substrate assessed as remaining total phosphatase activity incubated for 30 mins by colorimetric assay (Rvb = 68 +/- 2%) | Homo sapiens | 26 | ALA4477210 | cell-based format | Scientific Literature | |
3. | ALA4478411 | B | Suppression of okadaic acid-induced inhibition of PP1/PP2A in human SHSY-5Y cells at 0.1 uM using pNPP as substrate assessed as remaining Ser/Thr phosphatase activity incubated for 30 mins in presence of tyrosine phosphatase inhibitor sodium orthovanadate by colorimetric assay (Rvb = 61 +/- 3%) | Homo sapiens | 26 | ALA4477210 | cell-based format | Scientific Literature | |
4. | ALA4478412 | F | Neuroprotective activity in rat cortical motor neurons assessed as reversal of veratridine-induced cytotoxicity at 1 uM preincubated for 24 hrs followed by coincubation with veratridine for 24 hrs by MTT assay | Rattus norvegicus | 25 | ALA4477210 | cell-based format | Scientific Literature | |
5. | ALA4478413 | F | Neuroprotective activity in human SH-SY5Y cells assessed as reversal of okadaic acid-induced cytotoxicity at 0.1 uM preincubated for 24 hrs followed by coincubation with okadaic acid for 24 hrs by MTT assay | Homo sapiens | 26 | ALA4477210 | cell-based format | Scientific Literature | |
6. | ALA4478416 | A | Cytotoxicity against human SH-SY5Y cells assessed as reduction of cell viability at <10 uM incubated for 48 hrs by MTT assay | Homo sapiens | 24 | ALA4477210 | cell-based format | Scientific Literature |