# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4427245 | Functional | Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as L-glutamate-induced intracellular calcium mobilization incubated for 20 mins before L-glutamate addition | Homo sapiens | 23 | ALA4425158 | cell-based format | Scientific Literature | |
2. | ALA4427246 | Physicochemical | Aqueous solubility of the compound at pH 7.4 | 3 | ALA4425158 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4427247 | Physicochemical | Aqueous solubility of the compound at pH 1.2 | 3 | ALA4425158 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4427248 | ADME | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature | |
5. | ALA4427249 | ADME | Metabolic stability in rat liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4425158 | microsome format | Scientific Literature | |
6. | ALA4427250 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature | |
7. | ALA4427251 | ADME | Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature | |
8. | ALA4427252 | ADME | Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature | |
9. | ALA4427253 | ADME | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature | |
10. | ALA4427254 | ADME | Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature | |
11. | ALA4427255 | ADME | Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature | |
12. | ALA4427256 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature |