# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4355673 | Binding | Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay | Homo sapiens | 18 | ALA4354804 | cell-based format | Scientific Literature | |
2. | ALA4355674 | Binding | Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay | Homo sapiens | 18 | ALA4354804 | cell-based format | Scientific Literature | |
3. | ALA4355675 | Binding | Selectivity index, ratio of IC50 for recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay to IC50 for recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay | Homo sapiens | 18 | ALA4354804 | cell-based format | Scientific Literature | |
4. | ALA4355702 | ADME | Half life in human liver microsomes in presence of NADPH | Homo sapiens | 2 | ALA4354804 | microsome format | Scientific Literature | |
5. | ALA4355703 | ADME | Half life in mouse liver microsomes in presence of NADPH | Mus musculus | 2 | ALA4354804 | microsome format | Scientific Literature | |
6. | ALA4355736 | Toxicity | Genotoxicity against Salmonella Typhimurium TA97A assessed as revertant colonies at 0.075 to 250 ug/well by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | ALA4354804 | organism-based format | Scientific Literature | |
7. | ALA4355737 | Toxicity | Genotoxicity against Salmonella Typhimurium TA97A assessed as revertant colonies at 0.075 to 250 ug/well in presence of mammalian microsomal enzyme S9 mix by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | ALA4354804 | organism-based format | Scientific Literature | |
8. | ALA4355738 | Toxicity | Genotoxicity against Salmonella Typhimurium TA1537 assessed as revertant colonies at 0.075 to 250 ug/well by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | ALA4354804 | organism-based format | Scientific Literature | |
9. | ALA4355739 | Toxicity | Genotoxicity against Salmonella Typhimurium TA1537 assessed as revertant colonies at 0.075 to 250 ug/well in presence of mammalian microsomal enzyme S9 mix by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | ALA4354804 | organism-based format | Scientific Literature |