# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4388226 | A | Growth inhibition of trypomastigote form of Trypanosoma cruzi Y infected in human U2OS cells at 50 uM measured after 72 hrs by DRAQ5 DNA dye based confocal microscopic analysis relative to control | Trypanosoma cruzi | 42 | organism-based format | Scientific Literature | ||
2. | ALA4388227 | A | Growth inhibition of luciferase expressing Leishmania infantum axenic amastigotes infected in human THP1 cells at 10 uM measured after 72 hrs by steady-glo luminescence assay relative to control | Leishmania infantum | 42 | organism-based format | Scientific Literature | ||
3. | ALA4388230 | B | Inhibition of N-terminal His-tagged Trypanosoma brucei pteridine reductase 1 at 50 uM using di-hydrobiopterine as substrate measured at 1 min interval for 50 mins in presence of NADPH relative to control | Trypanosoma brucei | 42 | assay format | Scientific Literature | ||
4. | ALA4388232 | B | Inhibition of Leishmania major pteridine reductase 1 at 50 uM using di-hydrobiopterine as substrate in presence of NADPH relative to control | Leishmania major | 42 | single protein format | Scientific Literature | ||
5. | ALA4388233 | A | Growth inhibition of Trypanosoma brucei bloodstream forms at 10 uM measured after 72 hrs by resazurin-based fluorescence assay relative to control | Trypanosoma brucei | 42 | organism-based format | Scientific Literature | ||
6. | ALA4388237 | B | Displacement of Tracer Red from human ERG by fluorescence polarization assay | Homo sapiens | 43 | single protein format | Scientific Literature | ||
7. | ALA4388238 | A | Inhibition of human CYP1A2 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
8. | ALA4388239 | A | Inhibition of human CYP2C9 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
9. | ALA4388240 | A | Inhibition of human CYP2C19 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
10. | ALA4388241 | A | Inhibition of human CYP2D6 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
11. | ALA4388242 | A | Inhibition of human CYP3A4 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
12. | ALA4388243 | A | Cytotoxicity against human A549 cells after 48 hrs by Celltiter-glo assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
13. | ALA4388244 | A | Cytotoxicity against human THP1 cells after 72 hrs by MTT assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
14. | ALA4388245 | A | Cytotoxicity against human U2OS cells assessed as reduction in cell number | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
15. | ALA4388246 | T | Mitochondrial toxicity in human 786-O cells measured after 6 hrs by MitoTracker Red chloromethyl-X-rosamine based assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
16. | ALA4388274 | B | Selectivity ratio of IC50 for Leishmania major pteridine reductase 1 to IC50 for N-terminal His-tagged Trypanosoma brucei pteridine reductase 1 | 42 | assay format | Scientific Literature |