#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4346466	B	Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) assessed as relative fluorescence intensity incubated for 4 hrs by 8-NBD-cAMP competition binding assay relative to control	Homo sapiens	57		assay format	Scientific Literature
2.	ALA4346467	B	Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated for 4 hrs by 8-NBD-cAMP competition binding assay	Homo sapiens	6		assay format	Scientific Literature
3.	ALA4346474	B	Activation of recombinant EPAC1 (149 to 881 residues) (unknown origin) assessed as stimulation of dissociation of fluorescent MANT-GDP from recombinant Rap1b at 10 uM in presence of excess nonfluorescent nucleotides by fluorescence based in-vitro GEF assay relative to cAMP	Homo sapiens	6		single protein format	Scientific Literature
4.	ALA4346475	A	Activation of PKA in human U2OS cells stably transfected with EPAC1 assessed as increase in VASP phosphorylation at 100 uM by Western blot analysis	Homo sapiens	6		cell-based format	Scientific Literature
5.	ALA4346476	B	Activation of EPAC1 (unknown origin) expressed in U2OS cells at 100 uM incubated for 10 mins using GST-RalGDS-RBD by Western blot analysis based active GTP-bound Rap1 pull down assay	Homo sapiens	6		cell-based format	Scientific Literature
6.	ALA4346477	B	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring pSTAT3 protein levels at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	5		cell-based format	Scientific Literature
7.	ALA4346478	B	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring pERK protein levels at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	5		cell-based format	Scientific Literature
8.	ALA4346479	B	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring pAKT protein levels at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	3		cell-based format	Scientific Literature
9.	ALA4346480	B	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring VCAM1 protein expression at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	5		cell-based format	Scientific Literature
10.	ALA4346481	B	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring ICAM1 protein expression at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	4		cell-based format	Scientific Literature
11.	ALA4346482	B	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring SELE protein expression at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	4		cell-based format	Scientific Literature