| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4399995 | B | Inhibition of recombinant human His-tagged TrkA kinase domain (441-796 residues) expressed in baculovirus expression system at 10 uM incubated with enzyme/ATP mixture for 20 mins by HTRF assay relative to control | Homo sapiens | 30 | assay format | Scientific Literature | ||
| 2. | ALA4399996 | B | Inhibition of recombinant human His-tagged TrkA kinase domain (441-796 residues) expressed in baculovirus expression system at 1 uM incubated with enzyme/ATP mixture for 20 mins by HTRF assay relative to control | Homo sapiens | 30 | assay format | Scientific Literature | ||
| 3. | ALA4399997 | B | Inhibition of recombinant human His-tagged TrkA kinase domain (441-796 residues) expressed in baculovirus expression system incubated with enzyme/ATP mixture for 20 mins by HTRF assay | Homo sapiens | 31 | assay format | Scientific Literature | ||
| 4. | ALA4399998 | B | Inhibition of recombinant full length human TrkA transfected in CHO cells assessed as inhibition of NGF-stimulated calcium influx by FLIPR assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 5. | ALA4399999 | B | Inhibition of recombinant full length human TrkB transfected in CHO cells assessed as inhibition of NGF-stimulated calcium influx by FLIPR assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 6. | ALA4400000 | B | Binding affinity to recombinant human biotinylated and N-terminal DYKDDDDK-tagged TrkA kinase domain (436-790 residues) expressed in Sf21 cells assessed as association rate constant by SPR based singe cylce kinetics analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4400001 | B | Binding affinity to recombinant human biotinylated and N-terminal DYKDDDDK-tagged TrkA kinase domain (436-790 residues) expressed in Sf21 cells assessed as dissociation rate constant by SPR based single cycle kinetics analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4400002 | B | Binding affinity to recombinant human biotinylated and N- terminal DYKDDDDK-tagged TrkA kinase domain (436-790 residues) expressed in Sf21 cells assessed as equilibrium constant by SPR based single cycle kinetics analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4400003 | B | Binding affinity to recombinant human biotinylated and N-terminal DYKDDDDK-tagged TrkB kinase domain (456-822 residues) expressed in sf21 cells assessed as association rate constant by SPR based single cycle kinetics analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4400004 | B | Binding affinity to recombinant human biotinylated and N-terminal DYKDDDDK-tagged TrkB kinase domain (456-822 residues) expressed in sf21 cells assessed as dissociation rate constant by SPR based single cycle kinetics analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4400005 | B | Binding affinity to recombinant human biotinylated and N-terminal DYKDDDDK-tagged TrkB kinase domain (456-822 residues) expressed in sf21 cells assessed as equilibrium constant by SPR based single cycle kinetics analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4400006 | B | Inhibition of inactive recombinant human His-tagged TrkA expressed in baculovirus expression system preincubated for 20 mins followed by ATP/CSKtide substarte addition further incubated for 2 hrs by caliper microfluidic mobility shift assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 13. | ALA4400007 | B | Inhibition of activated recombinant human His-tagged TrkA expressed in baculovirus expression system preincubated for 20 mins followed by ATP/CSKtide substarte addition further incubated for 2 hrs by caliper microfluidic mobility shift assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 14. | ALA4400008 | B | Inhibition of inactive recombinant human His-tagged TrkB expressed in baculovirus expression system preincubated for 20 mins followed by ATP/SRCtide substarte addition further incubated for 2 hrs by caliper microfluidic mobility shift assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 15. | ALA4400009 | B | Inhibition of activated recombinant human His-tagged TrkB expressed in baculovirus expression system preincubated for 20 mins followed by ATP/SRCtide substarte addition further incubated for 2 hrs by caliper microfluidic mobility shift assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 16. | ALA4400010 | B | Inhibition of TrkA in rat PC12 cells assessed as reduction in beta-NGF-induced neurite outgrowth incubated for 7 days by live cell imaging analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4400011 | A | Stability in dog liver microsomes assessed as half life | Canis lupus familiaris | 2 | microsome format | Scientific Literature | ||
| 18. | ALA4400012 | A | Stability in cat liver microsomes assessed as half life | Felis catus | 2 | microsome format | Scientific Literature | ||
| 19. | ALA4400013 | A | Apparent permeability across apical to basolateral side in MDCK cells | Canis lupus familiaris | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4400014 | A | Apparent permeability across basolateral to apical side in MDCK cells | Canis lupus familiaris | 2 | cell-based format | Scientific Literature |
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