# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4403338 | Binding | Inhibition of CDK7 (unknown origin) | Homo sapiens | 16 | ALA4402527 | single protein format | Scientific Literature | |
2. | ALA4403340 | Binding | Inhibition of CDK2 (unknown origin) | Homo sapiens | 12 | ALA4402527 | single protein format | Scientific Literature | |
3. | ALA4403344 | Binding | Inhibition of CDK9 (unknown origin) | Homo sapiens | 10 | ALA4402527 | single protein format | Scientific Literature | |
4. | ALA4742483 | Binding | Inhibition of CDK7/Cyclin H/MAT1 (unknown origin) using 5-FAM-CDK7tide peptide substrate incubated for 35 mins | Homo sapiens | 277 | ALA4742388 | protein complex format | Patent Bioactivity Data | |
5. | ALA4742484 | Binding | Inhibition of CDK2/Cyclin E (unknown origin) using 5-FAM-CDK7tide substrate incubated for 35 mins | Homo sapiens | 277 | ALA4742388 | protein complex format | Patent Bioactivity Data | |
6. | ALA4742485 | Binding | Inhibition of CDK12 (686 to 1082 residues) /Cyclin K (unknown origin) using 5-FAM-CDK9tide peptide substrate incubated for 3 hrs | Homo sapiens | 277 | ALA4742388 | protein complex format | Patent Bioactivity Data | |
7. | ALA4742486 | Binding | Inhibition of CDK9/Cyclin T1 (unknown origin) using 5-FAM-CDK9tide peptide substrate incubated for 15 mins | Homo sapiens | 277 | ALA4742388 | protein complex format | Patent Bioactivity Data | |
8. | ALA4742487 | Functional | Inhibition of cell proliferation of human A673 cells incubated for 72 hrs by CyQUANT assay | Homo sapiens | 277 | ALA4742388 | cell-based format | Patent Bioactivity Data | |
9. | ALA4742488 | Functional | Inhibition of cell proliferation of human HCC70 cells incubated for 72 hrs by CyQUANT assay | Homo sapiens | 277 | ALA4742388 | cell-based format | Patent Bioactivity Data | |
10. | ALA5043156 | ADME | Oral bioavailability in CD-1 mouse 5 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 12 | ALA5042485 | organism-based format | Scientific Literature | |
11. | ALA5043157 | ADME | Unbound clearance in CD-1 mouse at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 14 | ALA5042485 | organism-based format | Scientific Literature | |
12. | ALA5043158 | ADME | Apparent permeability across apical to basolateral side in MDCK cells | Canis lupus familiaris | 13 | ALA5042485 | cell-based format | Scientific Literature | |
13. | ALA5043159 | ADME | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 15 | ALA5042485 | microsome format | Scientific Literature | |
14. | ALA5043160 | Physicochemical | Lipophilicity, log D of compound | 15 | ALA5042485 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA5043162 | Binding | Inhibition of CDK2/cyclin E1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay | Homo sapiens | 15 | ALA5042485 | protein complex format | Scientific Literature | |
16. | ALA5043163 | Functional | Antiproliferative activity against human HCC70 cells incubated for 72 hrs by Celltiter-glo assay | Homo sapiens | 12 | ALA5042485 | cell-based format | Scientific Literature | |
17. | ALA5043164 | Binding | Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origin) expressed in baculovirus infected Sf9 cells by Surface plasmon resonance assay | Homo sapiens | 15 | ALA5042485 | cell-based format | Scientific Literature | |
18. | ALA5043165 | Binding | Inhibition of CDK9/cyclin T1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay | Homo sapiens | 15 | ALA5042485 | protein complex format | Scientific Literature | |
19. | ALA5043166 | Binding | Inhibition of CDK12/cyclin K (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay | Homo sapiens | 15 | ALA5042485 | protein complex format | Scientific Literature | |
20. | ALA5043167 | Binding | Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origin) expressed in baculovirus infected Sf9 cells assessed as binding constant (Koff) by Surface plasmon resonance assay | Homo sapiens | 4 | ALA5042485 | cell-based format | Scientific Literature |