| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4383636 | Functional | Leishmanicidal activity against promastigote stage of iRFP expressing Leishmania infantum BCN150 assessed as decrease in parasite viability after 72 hrs by fluorescence assay | Leishmania infantum | 14 | ALA4382214 | organism-based format | Scientific Literature | |
| 2. | ALA4383637 | Binding | Inhibition of Leishmania donovani Top1B expressed in Top1B deficient Saccharomyces cerevisiae EKY3 assessed as decrease in relaxation of supercoiled pSK DNA preincubated for 15 mins followed by DNA addition and measured after 2 to 16 mins by agarose gel electrophoresis | Leishmania donovani | 10 | ALA4382214 | assay format | Scientific Literature | |
| 3. | ALA4383638 | Functional | Leishmanicidal activity against amastigote stage of iRFP expressing Leishmania infantum BCN150 infected in BALB/c mouse splenocytes assessed as decrease in parasite viability by fluorescence assay | Leishmania infantum | 14 | ALA4382214 | organism-based format | Scientific Literature | |
| 4. | ALA4383639 | ADME | Cytotoxicity against BALB/c mouse splenocytes assessed as reduction in cell viability by alamar blue assay | Mus musculus | 14 | ALA4382214 | cell-based format | Scientific Literature | |
| 5. | ALA4383640 | Toxicity | Selectivity index, ratio of CC50 for BALB/c mouse splenocytes to EC50 for amastigote stage of iRFP expressing Leishmania infantum BCN150 infected in BALB/c mouse splenocytes | 14 | ALA4382214 | cell-based format | Scientific Literature | ||
| 6. | ALA4383647 | Binding | Inhibition of Leishmania donovani Top1B expressed in Top1B deficient Saccharomyces cerevisiae EKY3 assessed as decrease in relaxation of supercoiled pSK DNA preincubated for 15 mins followed by DNA addition and measured after 5 mins by agarose gel electrophoresis | Leishmania donovani | 14 | ALA4382214 | assay format | Scientific Literature | |
| 7. | ALA4383648 | Binding | Inhibition of human Top1B expressed in Top1B deficient Saccharomyces cerevisiae EKY3 assessed as decrease in relaxation of supercoiled pSK DNA preincubated for 15 mins followed by DNA addition and measured after 2 to 16 mins by agarose gel electrophoresis | Homo sapiens | 10 | ALA4382214 | assay format | Scientific Literature | |
| 8. | ALA4383655 | Binding | Inhibition of human Top1B expressed in Top1B deficient Saccharomyces cerevisiae EKY3 assessed as decrease in relaxation of supercoiled pSK DNA preincubated for 15 mins followed by DNA addition and measured after 5 mins by agarose gel electrophoresis | Homo sapiens | 14 | ALA4382214 | assay format | Scientific Literature |
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