# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4369567 | A | Binding affinity to human serum albumin at 0.49 mg/ml after 3 hrs by HPLC/HRMS analysis | Homo sapiens | 1 | ALA4368881 | single protein format | Scientific Literature | |
2. | ALA4369568 | A | Prodrug conversion assessed as Escherichia coli beta-glucuronidase mediated MMAE formation after 5 hrs using albumin-conjugated compound by HPLC/HRMS analysis | Escherichia coli | 1 | ALA4368881 | single protein format | Scientific Literature | |
3. | ALA4369569 | F | Inhibition of anchorage-independent colony formation in 3D culture of human LS174T cells at 5 nM measured after 3 days by soft agar colony formation assay | Homo sapiens | 2 | ALA4368881 | cell-based format | Scientific Literature | |
4. | ALA4369570 | F | Inhibition of anchorage-independent colony formation in 3D culture of human LS174T cells at 5 nM measured after 3 days in presence of beta-glucuronidase by soft agar colony formation assay | Homo sapiens | 2 | ALA4368881 | cell-based format | Scientific Literature | |
5. | ALA4369572 | F | Antitumor activity against human LS174T cells xenografted in athymic Balb/c mouse assessed as tumor growth inhibition at 3 mg/kg, iv administered on day 17 and 24 | Homo sapiens | 1 | ALA4368881 | organism-based format | Scientific Literature | |
6. | ALA4369574 | T | Toxicity in athymic Balb/c mouse xenografted with human LS174T cells assessed as effect on body weight at 3 mg/kg, iv administered on day 17 and 24 measured three times a week | Mus musculus | 1 | ALA4368881 | organism-based format | Scientific Literature |