# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4391927 | B | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method | Homo sapiens | 31 | ALA4390667 | single protein format | Scientific Literature | |
2. | ALA4391928 | B | Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method | Homo sapiens | 31 | ALA4390667 | single protein format | Scientific Literature | |
3. | ALA4391929 | B | Selectivity index, ratio of IC50 for recombinant human BChE to IC50 for recombinant human AChE | Homo sapiens | 31 | ALA4390667 | protein format | Scientific Literature | |
4. | ALA4391930 | B | Inhibition of HFIP pretreated amyloid beta (1-42) (unknown origin) self aggregation at 50 uM incubated for 24 hrs by thioflavin T based fluorescence assay relative to control | Homo sapiens | 30 | ALA4390667 | single protein format | Scientific Literature | |
5. | ALA4391932 | A | Effective permeability of the compound in PBS buffer at pH 7.4 at 100 uM after 3 to 6 hrs by PAMPA | 23 | ALA4390667 | assay format | Scientific Literature | ||
6. | ALA4391933 | B | Displacement of propidium iodide from peripheral binding site of electric eel AChE at 8 to 56 uM by spectrofluorometry | Electrophorus electricus | 1 | ALA4390667 | single protein format | Scientific Literature | |
7. | ALA4391934 | B | Displacement of propidium iodide from peripheral binding site of electric eel AChE assessed as dissociation constant at 8 to 56 uM by spectrofluorometry based Taylor and Lappi method | Electrophorus electricus | 1 | ALA4390667 | single protein format | Scientific Literature | |
8. | ALA4391935 | B | Inhibition of human AChE-induced amyloid beta aggregation (1-40) (unknown origin) aggregation at 100 uM incubated for 24 hrs by thioflavin T based fluorescence assay relative to control | Homo sapiens | 8 | ALA4390667 | single protein format | Scientific Literature | |
9. | ALA4391936 | A | Cytotoxicity against CHOK1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | Cricetulus griseus | 27 | ALA4390667 | cell-based format | Scientific Literature | |
10. | ALA4391937 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | Homo sapiens | 27 | ALA4390667 | cell-based format | Scientific Literature | |
11. | ALA4391938 | T | Toxicity in Wistar rat assessed as change in body weight weight at 70 mg/kg, ip after 24 and 48 hrs | Rattus norvegicus | 1 | ALA4390667 | organism-based format | Scientific Literature | |
12. | ALA4391939 | B | Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 mins | Rattus norvegicus | 26 | ALA4390667 | assay format | Scientific Literature | |
13. | ALA4391941 | T | Toxicity in ip dosed Wistar rat assessed as maximum tolerated dose measured during first 2 hrs then periodically for 48 hrs | Rattus norvegicus | 1 | ALA4390667 | organism-based format | Scientific Literature | |
14. | ALA4391942 | F | Antialzhemeric activity in Wistar rat model of scopolamine-induced cognition deficit assessed as effect on escape latency at 10 nM, icv dosed 60 mins prior to training trial by Morris water maze test | Rattus norvegicus | 1 | ALA4390667 | organism-based format | Scientific Literature | |
15. | ALA4391943 | F | Antialzhemeric activity in Wistar rat model of scopolamine-induced cognition deficit assessed as effect on distance moved at 10 nM, icv dosed 60 mins prior to training trial by Morris water maze test | Rattus norvegicus | 1 | ALA4390667 | organism-based format | Scientific Literature | |
16. | ALA4391944 | F | Antialzhemeric activity in Wistar rat model of scopolamine-induced cognition deficit assessed as effect on average distance from platform at 10 nM, icv dosed 60 mins prior to training trial by Morris water maze test | Rattus norvegicus | 1 | ALA4390667 | organism-based format | Scientific Literature | |
17. | ALA4391945 | F | Antialzhemeric activity in Wistar rat model of scopolamine-induced cognition deficit assessed as effect on time in target sector at 10 nM, icv dosed 60 mins prior to training trial by Morris water maze test | Rattus norvegicus | 1 | ALA4390667 | organism-based format | Scientific Literature | |
18. | ALA4391946 | F | Antialzhemeric activity in Wistar rat model of scopolamine-induced cognition deficit assessed as effect on distance moved at 100 nM, icv dosed 60 mins prior to training trial by Morris water maze test | Rattus norvegicus | 1 | ALA4390667 | organism-based format | Scientific Literature | |
19. | ALA4391947 | F | Antialzhemeric activity in Wistar rat model of scopolamine-induced cognition deficit assessed as effect on escape latency at 100 nM, icv dosed 60 mins prior to training trial by Morris water maze test | Rattus norvegicus | 1 | ALA4390667 | organism-based format | Scientific Literature | |
20. | ALA4391948 | F | Antialzhemeric activity in Wistar rat model of scopolamine-induced cognition deficit assessed as effect on average distance from platform at 100 nM, icv dosed 60 mins prior to training trial by Morris water maze test | Rattus norvegicus | 1 | ALA4390667 | organism-based format | Scientific Literature |