| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4381638 | Functional | Antiviral activity against Dengue virus 2 infected in human BE(2)-C cells assessed as reduction in NS3 protein expression at 3.125 to 6.25 uM treated during 0 to 3 hrs post infection by Western blot analysis | dengue virus type 2 | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 2. | ALA4381639 | Functional | Antiviral activity of Influenza A virus (H1N1) infected in human HMC3 cells assessed as reduction in nucleoprotein protein expression at 0.781 to 12.5 uM incubated for 24 hrs by immunofluorescence microscopy | Influenza A virus | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 3. | ALA4381640 | Functional | Antiviral activity against DENV-2 NGC-N infected in Stat1-/- mouse assessed as effect on overall mouse survival at 2 to 8 mg/kg/day, po dosed immediately following viral infection followed by daily dosing for 6 days | dengue virus type 2 | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 4. | ALA4381641 | Functional | Antiviral activity against DENV-2 NGC-N infected in Stat1-/- mouse assessed as time delay in mouse mortality at 2 mg/kg/day, po dosed immediately following viral infection followed by daily dosing for 6 days (Rvb = 9 days) | dengue virus type 2 | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 5. | ALA4381642 | Functional | Antiviral activity against DENV-2 NGC-N infected in Stat1-/- mouse assessed as overall mouse survival at 8 mg/kg, po dosed immediately following viral infection followed by daily dosing for 6 days (Rvb = 0%) | dengue virus type 2 | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 6. | ALA4381643 | Functional | Antiviral activity against DENV-2 NGC-N infected in Stat1-/- mouse assessed as overall mouse survival at 4 mg/kg, po dosed immediately following viral infection followed by daily dosing for 6 days (Rvb = 0%) | dengue virus type 2 | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 7. | ALA4381644 | Functional | Antiviral activity against Zika virus infected in human BE(2)-C cells assessed as NS3 protein expression at 6.25 uM treated during 3 to 24 hrs post infection by Western blot analysis (Rvb = 100%) | Zika virus | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 8. | ALA4381645 | Functional | Antiviral activity against Zika virus infected in human BE(2)-C cells assessed as NS3 protein expression at 3.125 uM treated during 3 to 24 hrs post infection by Western blot analysis (Rvb = 100%) | Zika virus | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 9. | ALA4381646 | Functional | Antiviral activity against Zika virus infected in human BE(2)-C cells assessed as NS3 protein expression at 6.25 uM treated during 0 to 3 hrs post infection by Western blot analysis (Rvb = 100%) | Zika virus | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 10. | ALA4381647 | Functional | Antiviral activity against Zika virus infected in human BE(2)-C cells assessed as NS3 protein expression at 3.125 uM treated during 0 to 3 hrs post infection by Western blot analysis (Rvb = 100%) | Zika virus | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 11. | ALA4381648 | Functional | Antiviral activity against eGFP-fused Dengue virus 2 infected in human BE(2)-C cells assessed as viral infection level by measuring intensity of eGFP emission from infected cells at 1.56 uM incubated for 24 hrs relative to control | dengue virus type 2 | 18 | ALA4376891 | organism-based format | Scientific Literature | |
| 12. | ALA4381649 | Functional | Antiviral activity against eGFP-fused Dengue virus 2 infected in human BE(2)-C cells assessed as viral infection level by measuring intensity of eGFP emission from infected cells at 3.13 uM incubated for 24 hrs relative to control | dengue virus type 2 | 18 | ALA4376891 | organism-based format | Scientific Literature | |
| 13. | ALA4381650 | ADME | Cytotoxicity against human BE(2)-C cells assessed as cell proliferation at 6.25 uM incubated overnight by XTT assay relative to control | Homo sapiens | 18 | ALA4376891 | cell-based format | Scientific Literature | |
| 14. | ALA4381651 | ADME | Cytotoxicity against human BE(2)-C cells assessed as reduction in cell viability up to 12.5 uM incubated overnight by LDH assay relative to control | Homo sapiens | 1 | ALA4376891 | cell-based format | Scientific Literature | |
| 15. | ALA4381652 | ADME | Cytotoxicity against human BE(2)-C cells assessed as reduction in cell proliferation up to 12.5 uM incubated overnight by XTT assay relative to control | Homo sapiens | 1 | ALA4376891 | cell-based format | Scientific Literature | |
| 16. | ALA4381653 | ADME | Cytotoxicity against human BE(2)-C cells assessed as reduction in cell viability up to 12.5 uM incubated overnight by trypan blue assay relative to control | Homo sapiens | 1 | ALA4376891 | cell-based format | Scientific Literature | |
| 17. | ALA4381654 | Functional | Antiviral activity against Dengue virus 2 infected in human BE(2)-C cells assessed as reduction in NS3 protein expression at 1.56 to 12.5 uM incubated for 48 hrs by immunofluorescence microscopy | dengue virus type 2 | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 18. | ALA4381655 | Functional | Antiviral activity against Dengue virus 2 infected in human BE(2)-C cells assessed as NS3 protein expression at 0.39 uM incubated for 48 hrs by Western blot analysis (Rvb = 100%) | dengue virus type 2 | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 19. | ALA4381656 | Functional | Antiviral activity against Dengue virus 2 infected in human BE(2)-C cells assessed as NS3 protein expression at 0.78 uM incubated for 48 hrs by Western blot analysis (Rvb = 100%) | dengue virus type 2 | 1 | ALA4376891 | organism-based format | Scientific Literature | |
| 20. | ALA4381657 | Functional | Antiviral activity against Dengue virus 2 infected in human BE(2)-C cells assessed as NS3 protein expression at 1.56 uM incubated for 48 hrs by Western blot analysis (Rvb = 100%) | dengue virus type 2 | 1 | ALA4376891 | organism-based format | Scientific Literature |
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