# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4356423 | B | Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
2. | ALA4356424 | B | Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
3. | ALA4356425 | A | Cytotoxicity against human HEK293 cells transfected with human TLR8 assessed as reduction in cell viability up to 5 uM incubated for 16 hrs by WST-1 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4356426 | B | Inhibition of human TLR4 expressed in HEK293 cells assessed as reduction in LPS-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4356427 | B | Inhibition of human TLR3 expressed in HEK293 cells assessed as reduction in poly(I:C)-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4356428 | B | Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in resiquimod-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
7. | ALA4356431 | B | Inhibition of human TLR1/2 expressed in HEK293 cells assessed as reduction in Pam3CSK4-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4356432 | B | Inhibition of human TLR2/6 expressed in HEK293 cells assessed as reduction in Pam2CSK4-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4356433 | B | Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in Pam3CSK4-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4356434 | B | Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 14 | cell-based format | Scientific Literature |