# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4310037 | Functional | Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mobilization preincubated for 142 secs followed by EC20 glutamate addition and subsequent EC80 glutamate addition after 147 secs by Fluo-4-AM dye based fluorescence assay | Homo sapiens | 50 | ALA4308847 | cell-based format | Scientific Literature | |
2. | ALA4310038 | Functional | Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mobilization preincubated for 142 secs followed by EC20 glutamate addition and measured after 147 secs by Fluo-4-AM dye based fluorescence assay relative to control | Homo sapiens | 49 | ALA4308847 | cell-based format | Scientific Literature | |
3. | ALA4310040 | ADME | Intrinsic clearance in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 28 | ALA4308847 | microsome format | Scientific Literature | |
4. | ALA4310041 | ADME | Intrinsic clearance in rat liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 28 | ALA4308847 | microsome format | Scientific Literature | |
5. | ALA4310042 | ADME | Fraction unbound in human plasma after 4 hrs by equilibrium dialysis method | Homo sapiens | 28 | ALA4308847 | cell-free format | Scientific Literature | |
6. | ALA4310043 | ADME | Fraction unbound in rat plasma after 4 hrs by equilibrium dialysis method | Rattus norvegicus | 28 | ALA4308847 | cell-free format | Scientific Literature | |
7. | ALA4310044 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by substrate addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 28 | ALA4308847 | microsome format | Scientific Literature | |
8. | ALA4310045 | Binding | Positive allosteric modulation of rat mGlu4 receptor expressed in HEK cells co-expressing GIRK1/2 assessed as increase in glutamate-induced thallium flux preincubated for 140 secs followed by glutamate addition and measured after 2.5 mins by FluoZin-2-AM dye based fluorescence assay | Rattus norvegicus | 28 | ALA4308847 | cell-based format | Scientific Literature | |
9. | ALA4310046 | Binding | Positive allosteric modulation of rat mGlu4 receptor expressed in HEK cells co-expressing GIRK1/2 assessed as increase in glutamate-induced thallium flux preincubated for 140 secs followed by glutamate addition and measured after 2.5 mins by FluoZin-2-AM dye based fluorescence assay relative to control | Rattus norvegicus | 28 | ALA4308847 | cell-based format | Scientific Literature |