# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4340227 | F | Antiproliferative activity against human KOPTK1 cells harboring activating Notch1 gene mutations assessed as reduction in cell viability at 2.5 uM incubated for 36 hrs by MTS assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
2. | ALA4340228 | B | Inhibition of NOTCH1 signalling in human KOPTK1 cells harboring activating Notch1 gene mutations assessed as reduction in N1Val protein expression at 2.5 uM incubated for 36 hrs by Western blot analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
3. | ALA4340229 | B | Inhibition of NOTCH1 signalling in human KOPTK1 cells harboring activating Notch1 gene mutations assessed as reduction in DELTEX1 mRNA expression at 2.5 uM incubated for 36 hrs by RT-PCR analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA4340230 | F | Antiproliferative activity against human KOPTK1 cells harboring activating Notch1 gene mutations assessed as reduction in cell viability incubated for 36 hrs by MTS assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
5. | ALA4340231 | F | Induction of cell death in human KOPTK1 cells harboring activating Notch1 gene mutations assessed as increase in p27kip protein expression at 2.5 uM incubated for 36 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
6. | ALA4340232 | F | Induction of cell death in human KOPTK1 cells harboring activating Notch1 gene mutations assessed as increase in cleaved PARP protein expression at 2.5 uM incubated for 36 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
7. | ALA4340233 | F | Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability at 2.5 uM incubated for 36 hrs by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4340234 | F | Antiproliferative activity against immortalized human HaCaT cells assessed as reduction in cell viability at 2.5 uM incubated for 36 hrs by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature |