# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4309283 | B | Binding affinity to human RFC expressed in Chinese hamster PC43-10 cells assessed as antiproliferative activity measured as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
2. | ALA4309284 | A | Antiproliferative activity in Chinese hamster R2 cells deficient in RFC, PCFT, and FRalpha assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Cricetulus griseus | 12 | cell-based format | Scientific Literature | ||
3. | ALA4309285 | B | Binding affinity to human FRalpha expressed in Chinese hamster RT16 cells assessed as antiproliferative activity measured as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
4. | ALA4309286 | B | Binding affinity to human FRbeta expressed in Chinese hamster D4 cells assessed as antiproliferative activity measured as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
5. | ALA4309287 | B | Binding affinity to human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as antiproliferative activity measured as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
6. | ALA4309288 | B | Binding affinity to human RFC2 expressed in human HeLa R1-11 cells assessed as antiproliferative activity measured as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
7. | ALA4309289 | B | Binding affinity to human PCFT4 expressed in human HeLa R1-11 cells assessed as antiproliferative activity measured as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
8. | ALA4309290 | B | Binding affinity to human FR2 expressed in human HeLa R1-11 cells assessed as antiproliferative activity measured as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
9. | ALA4309293 | B | Inhibition of human RFC2 expressed in human HeLa R1-11 cells assessed as reduction in [3H]MTX uptake at pH 7.2 at 10 uM measured over 2 mins relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
10. | ALA4309294 | B | Inhibition of human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as reduction in [3H]MTX uptake at pH 5.5 measured over 2 mins by Dixon plot analysis | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
11. | ALA4309295 | B | Inhibition of human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as reduction in [3H]MTX uptake at pH 5.5 at 1 uM measured over 2 mins relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
12. | ALA4309296 | B | Inhibition of human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as reduction in [3H]MTX uptake at pH 5.5 at 10 uM measured over 2 mins relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
13. | ALA4309297 | B | Inhibition of human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as reduction in [3H]MTX uptake at pH 5.5 at 1 to 10 uM measured over 2 mins | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
14. | ALA4309298 | B | Displacement of [3H]folic acid from human FRalpha expressed in Chinese hamster RT16 cells at 10 to 1000 nM after 15 mins | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
15. | ALA4309299 | B | Displacement of [3H]folic acid from human FRbeta expressed in Chinese hamster D4 cells at 10 to 1000 nM after 15 mins | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
16. | ALA4309300 | B | Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrs | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
17. | ALA4309301 | F | Antiproliferative activity against human IGROV1 cells at 1 to 1000 nM in presence of 320 uM AICA after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
18. | ALA4309302 | F | Antiproliferative activity against human IGROV1 cells at 1 to 1000 nM in presence of 10 uM thymidine after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
19. | ALA4309303 | F | Antiproliferative activity against human IGROV1 cells at 1 to 1000 nM in presence of 60 uM adenosine after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
20. | ALA4309307 | F | Antiproliferative activity against FRalpha knockout human IGROV1 KD10 cells after 96 hrs by Cell-Titer Blue assay | Homo sapiens | 12 | cell-based format | Scientific Literature |