| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4333228 | B | Displacement of Ac-ARTEVHLRKS-(Ahx)-(Ahx)-K(5-FAM)-NH2 from recombinant full-length human N-terminal His6-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3) at 100 uM after 2 hrs by fluorescence polarization assay relative to control | Homo sapiens | 27 | ALA4330131 | assay format | Scientific Literature | |
| 2. | ALA4333229 | B | Displacement of Ac-ARTEVHLRKS-(Ahx)-(Ahx)-K(5-FAM)-NH2 from recombinant full-length human N-terminal His6-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3) after 2 hrs by fluorescence polarization assay | Homo sapiens | 25 | ALA4330131 | assay format | Scientific Literature | |
| 3. | ALA4333231 | B | Inhibition of MLL2 (unknown origin) using SAM as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by Alphalisa assay | Homo sapiens | 1 | ALA4330131 | single protein format | Scientific Literature | |
| 4. | ALA4333232 | B | Inhibition of PRMT1 (unknown origin) using SAM as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by Alphalisa assay | Homo sapiens | 1 | ALA4330131 | single protein format | Scientific Literature | |
| 5. | ALA4333233 | B | Inhibition of SETD1B (unknown origin) using SAM as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by Alphalisa assay | Homo sapiens | 1 | ALA4330131 | single protein format | Scientific Literature | |
| 6. | ALA4333234 | B | Inhibition of G9a (unknown origin) using SAM as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by Alphalisa assay | Homo sapiens | 1 | ALA4330131 | single protein format | Scientific Literature | |
| 7. | ALA4333235 | B | Selectivity ratio of IC50 for MLL2 (unknown origin) to IC50 for displacement of Ac-ARTEVHLRKS-(Ahx)-(Ahx)-K(5-FAM)-NH2 from recombinant full-length human N-terminal His6-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | ALA4330131 | assay format | Scientific Literature | |
| 8. | ALA4333236 | B | Selectivity ratio of IC50 for PRMT1 (unknown origin) to IC50 for displacement of Ac-ARTEVHLRKS-(Ahx)-(Ahx)-K(5-FAM)-NH2 from recombinant full-length human N-terminal His6-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | ALA4330131 | assay format | Scientific Literature | |
| 9. | ALA4333237 | B | Selectivity ratio of IC50 for SETD1B (unknown origin) to IC50 for displacement of Ac-ARTEVHLRKS-(Ahx)-(Ahx)-K(5-FAM)-NH2 from recombinant full-length human N-terminal His6-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | ALA4330131 | assay format | Scientific Literature | |
| 10. | ALA4333238 | B | Selectivity ratio of IC50 for G9a (unknown origin) to IC50 for displacement of Ac-ARTEVHLRKS-(Ahx)-(Ahx)-K(5-FAM)-NH2 from recombinant full-length human N-terminal His6-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | ALA4330131 | assay format | Scientific Literature | |
| 11. | ALA4333239 | B | Binding affinity to recombinant full-length human N-terminal His6-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3) at 120 secs by surface plasmon resonance analysis | Homo sapiens | 1 | ALA4330131 | assay format | Scientific Literature | |
| 12. | ALA4333240 | B | Reversible inhibition of recombinant full-length human N-terminal His6-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation time by surface plasmon resonance analysis | Homo sapiens | 1 | ALA4330131 | assay format | Scientific Literature | |
| 13. | ALA4333241 | B | Binding affinity to recombinant full-length human N-terminal His6-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance analysis | Homo sapiens | 2 | ALA4330131 | assay format | Scientific Literature | |
| 14. | ALA4333242 | F | Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 5 days by Celltiter-Glo luminescent assay | Homo sapiens | 1 | ALA4330131 | cell-based format | Scientific Literature | |
| 15. | ALA4333243 | F | Antiproliferative activity against human K562 cells assessed as cell growth inhibition after 5 days by Celltiter-Glo luminescent assay | Homo sapiens | 1 | ALA4330131 | cell-based format | Scientific Literature |
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