# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4347273 | Binding | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx at 30 uM by Fluo-4-AM dye based fluorescence assay relative to calcimycin | Homo sapiens | 20 | ALA4346663 | cell-based format | Scientific Literature | |
2. | ALA4347274 | Binding | Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx at 100 uM incubated for 10 mins prior to CA addition by Fluo-4-AM dye based fluorescence assay relative to CA | Homo sapiens | 19 | ALA4346663 | cell-based format | Scientific Literature | |
3. | ALA4347275 | Binding | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | Homo sapiens | 37 | ALA4346663 | cell-based format | Scientific Literature | |
4. | ALA4347276 | Binding | Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of CA-induced increase in calcium influx incubated for 10 mins prior to CA addition by Fluo-4-AM dye based fluorescence assayy | Homo sapiens | 23 | ALA4346663 | cell-based format | Scientific Literature | |
5. | ALA4347277 | Binding | Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in calcium influx at 30 uM by Fluo-4-AM dye based fluorescence assay relative to calcimycin | Homo sapiens | 19 | ALA4346663 | cell-based format | Scientific Literature | |
6. | ALA4347278 | Binding | Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in calcium influx at 100 uM incubated for 10 mins prior to WS5 challenge by Fluo-4-AM dye based fluorescence assay relative to WS5 | Homo sapiens | 19 | ALA4346663 | cell-based format | Scientific Literature | |
7. | ALA4347279 | Binding | Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition in WS5-induced increase in calcium influx incubated for 10 mins prior to WS5 challenge by Fluo-4-AM dye based fluorescence assay | Homo sapiens | 19 | ALA4346663 | cell-based format | Scientific Literature | |
8. | ALA4347300 | Physicochemical | Dissociation constant, pKa of the compound at pH 7.4 | 35 | ALA4346663 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4347301 | Binding | Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in calcium influx at 100 uM by Fluo-4-AM dye based fluorescence assay relative to calcimycin | Homo sapiens | 21 | ALA4346663 | cell-based format | Scientific Literature | |
10. | ALA4347309 | Binding | Agonist activity at human TRPA1 Cys261Ala mutant expressed in HEK293 cells assessed as Ca2+ influx at 30 uM by fluorescence assay | Homo sapiens | 9 | ALA4346663 | cell-based format | Scientific Literature | |
11. | ALA4347316 | Binding | Agonist activity at human TRPA1 Phe909Ala mutant expressed in HEK293 cells assessed as Ca2+ influx at 30 uM by fluorescence assay | Homo sapiens | 12 | ALA4346663 | cell-based format | Scientific Literature | |
12. | ALA4347321 | Binding | Agonist activity at human TRPA1 Phe944Ala mutant expressed in HEK293 cells assessed as Ca2+ influx at 30 uM by fluorescence assay | Homo sapiens | 9 | ALA4346663 | cell-based format | Scientific Literature | |
13. | ALA4835403 | Binding | Inhibition of human TRPM2 expressed in HEK293T cells assessed as suppression of H2O2-induced calcium flux at 1 uM measured after 30 mins by Fluo-3/AM assay | Homo sapiens | 60 | ALA4834416 | cell-based format | Scientific Literature | |
14. | ALA4835404 | Binding | Inhibition of human TRPM2 expressed in HEK293T cells assessed as suppression of H2O2-induced calcium flux at 0.3 uM measured after 30 mins by Fluo-3/AM assay | Homo sapiens | 12 | ALA4834416 | cell-based format | Scientific Literature |