| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4370819 | B | Inhibition of Leucyl-tRNA synthetase-mediated mTORC1 signaling activation in human HEK293 cells assessed as reduction in leucine-induced S6K phosphorylation at 200 uM preincubated for 50 mins followed by leucine-stimulation and measured after 10 mins by Western blot analysis | Homo sapiens | 48 | cell-based format | Scientific Literature | ||
| 2. | ALA4370820 | B | Inhibition of mTORC2 signaling in human HEK293 cells assessed as reduction in leucine-induced AKT phosphorylation at 200 uM preincubated for 50 mins followed by leucine-stimulation and measured after 10 mins by Western blot analysis | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 3. | ALA4370821 | F | Effect on leucine-induced AKT levels in human HEK293 cells at 200 uM preincubated for 50 mins followed by leucine-stimulation and measured after 10 mins by Western blot analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 4. | ALA4681668 | B | Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 5. | ALA4681669 | B | Inhibition of catalytic activity of LRS in HEK293 cells assessed as reduction in mTORC1 activation by measuring leucine-induced S6K phosphorylation at 12.5 to 200 uM by immunoblotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4681671 | B | Inhibition of flag-tagged mTORC1 (unknown origin) at 200 uM | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 7. | ALA4681672 | F | Cytotoxicity in human A549 cells by sulforhodamine B colorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA4681673 | F | Cytotoxicity in human HCT-116 cells by sulforhodamine B colorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA4681674 | F | Cytotoxicity in human K562 cells by sulforhodamine B colorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4681675 | F | Cytotoxicity in human MDA-MB-231 cells by sulforhodamine B colorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4681676 | F | Cytotoxicity in human SK-HEP1 cells by sulforhodamine B colorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4681677 | F | Cytotoxicity in human SNU-638 cells by sulforhodamine B colorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4681678 | A | Cytotoxicity in human MRC5 cells by sulforhodamine B colorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature |
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