# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4380980 | ADME | AUC (0 to 8 hrs) in Wistar rat at 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4376878 | organism-based format | Scientific Literature | |
2. | ALA4380981 | ADME | Volume of distribution in Wistar rat at 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4376878 | organism-based format | Scientific Literature | |
3. | ALA4380982 | ADME | Elimination half-life in Wistar rat at 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4376878 | organism-based format | Scientific Literature | |
4. | ALA4380983 | ADME | Agonist activity at C3a receptor in human MDM cells assessed as induction of intracellular calcium release measured at 1 sec interval for => 200 secs by Fluo-3 AM dye-based FLIPR assay | Homo sapiens | 28 | ALA4376878 | cell-based format | Scientific Literature | |
5. | ALA4380985 | Functional | Antagonist activity at C3a receptor in human MDM cells assessed as inhibition of C3a-induced intracellular calcium release preincubated for 30 mins followed by C3a addition and measured at 1 sec interval for => 200 secs by Fluo-3 AM dye-based FLIPR assay | Homo sapiens | 28 | ALA4376878 | cell-based format | Scientific Literature | |
6. | ALA4380989 | ADME | Stability of the compound in rat plasma at 1 mM measured after 4 hrs by LC-MS analysis | Rattus norvegicus | 4 | ALA4376878 | cell-free format | Scientific Literature | |
7. | ALA4380991 | ADME | Stability of the compound in rat liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 1 hr by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4376878 | microsome format | Scientific Literature | |
8. | ALA4380995 | ADME | Clearance in Wistar rat at 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4376878 | organism-based format | Scientific Literature | |
9. | ALA4380996 | ADME | AUC (0 to 8 hrs) in Wistar rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4376878 | organism-based format | Scientific Literature | |
10. | ALA4380997 | ADME | Tmax in Wistar rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4376878 | organism-based format | Scientific Literature | |
11. | ALA4380998 | ADME | Cmax in Wistar rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4376878 | organism-based format | Scientific Literature | |
12. | ALA4381003 | Functional | Antiinflammatory activity in Wistar rat model of BR103-induced paw edema assessed as reduction in hind paw swelling at 10 mg/kg, po administered via gavage pretreated for 2 hrs followed by BR103 challenge and measured after 30 mins by digital caliper method relative to control | Rattus norvegicus | 4 | ALA4376878 | organism-based format | Scientific Literature |