# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4335366 | Functional | Antiviral activity against GFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutant infected in human Huh7.5.1 cells assessed as reduction in viral infection at 10 uM preincubated for 2 hrs followed by viral infection and measured after 48 hrs by epifluorescence microscopic analysis relative to control | Hepacivirus hominis | 36 | ALA4334439 | organism-based format | Scientific Literature | |
2. | ALA4335367 | Functional | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutant infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days by qRT-PCR analysis | Hepacivirus hominis | 36 | ALA4334439 | organism-based format | Scientific Literature | |
3. | ALA4335416 | Binding | Inhibition of C-terminal 6-His tagged recombinant human DHODH N-terminal domain delta29 mutant expressed in Escherichia coli BL21(DE3) using dihydroorotate as substrate measured every 30 secs for 6 mins by DCIP dye based assay | Homo sapiens | 4 | ALA4334439 | assay format | Scientific Literature |