# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4367190 | Binding | Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay | Homo sapiens | 21 | ALA4364292 | cell-based format | Scientific Literature | |
2. | ALA4367191 | Functional | Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay | Homo sapiens | 30 | ALA4364292 | cell-based format | Scientific Literature | |
3. | ALA4367194 | ADME | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 2 | ALA4364292 | single protein format | Scientific Literature | |
4. | ALA4367195 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | ALA4364292 | single protein format | Scientific Literature | |
5. | ALA4367196 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 2 | ALA4364292 | single protein format | Scientific Literature | |
6. | ALA4367197 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | ALA4364292 | single protein format | Scientific Literature | |
7. | ALA4367198 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA4364292 | single protein format | Scientific Literature | |
8. | ALA4367199 | ADME | Stability in human hepatocytes assessed as compound remaining incubated for 60 mins under shaking condition by LC-MS/MS analysis | Homo sapiens | 8 | ALA4364292 | cell-based format | Scientific Literature | |
9. | ALA4367200 | ADME | Stability in rat hepatocytes assessed as compound remaining incubated for 60 mins under shaking condition by LC-MS/MS analysis | Rattus norvegicus | 8 | ALA4364292 | cell-based format | Scientific Literature | |
10. | ALA4367201 | ADME | Hepatic clearance in rat at 0.5 mg/kg, iv or 2 mg/kg, po | Rattus norvegicus | 2 | ALA4364292 | organism-based format | Scientific Literature | |
11. | ALA4367202 | ADME | Volume of distribution at steady state in rat at 0.5 mg/kg, iv or 2 mg/kg, po | Rattus norvegicus | 2 | ALA4364292 | organism-based format | Scientific Literature | |
12. | ALA4367203 | ADME | Terminal half-life in rat at 0.5 mg/kg, iv or 2 mg/kg, po | Rattus norvegicus | 2 | ALA4364292 | organism-based format | Scientific Literature | |
13. | ALA4367204 | ADME | AUC(0 to infinity) in rat at 2 mg/kg, po | Rattus norvegicus | 2 | ALA4364292 | organism-based format | Scientific Literature | |
14. | ALA4367205 | ADME | Oral bioavailability in rat at 2 mg/kg, po | Rattus norvegicus | 2 | ALA4364292 | organism-based format | Scientific Literature |