# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4325791 | Binding | Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and measured by FRET assay | Homo sapiens | 36 | ALA4321885 | assay format | Scientific Literature | |
2. | ALA4325792 | Physicochemical | Solubility of the compound in pH 7.4 phosphate buffered saline by HPLC-MS analysis | 2 | ALA4321885 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4325794 | ADME | Cytotoxicity against NHDF cells assessed as reduction in cell viability up to 100 uM measured after 72 hrs by Celltiter-glo assay | Homo sapiens | 3 | ALA4321885 | cell-based format | Scientific Literature | |
4. | ALA4325795 | ADME | Cytotoxicity against human PBMC cells assessed as reduction in cell viability up to 100 uM measured after 72 hrs by Celltiter-glo assay | Homo sapiens | 3 | ALA4321885 | cell-based format | Scientific Literature | |
5. | ALA4325797 | Binding | Inhibition of recombinant human N-terminal FLAG-tagged renin (67 to 406 residues) expressed in HEK cells at 50 nM using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(Dabcyl)-Arg as substrate preincubated for 10 mins followed by substrate addition and measured by FRET assay | Homo sapiens | 31 | ALA4321885 | cell-based format | Scientific Literature | |
6. | ALA4325798 | Binding | Inhibition of recombinant human C-terminal 10His-tagged BACE1 expressed in mouse NS0 cells at 50 nM using Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg as substrate preincubated for 10 mins followed by substrate addition and measured by FRET assay | Homo sapiens | 31 | ALA4321885 | cell-based format | Scientific Literature | |
7. | ALA4325799 | Binding | Inhibition of HIV1 protease at 50 nM using Abz-Tyr-Ile-Nle-Nph-Gln-Arg as substrate preincubated for 10 mins followed by substrate addition and measured by FRET assay | Human immunodeficiency virus 1 | 31 | ALA4321885 | single protein format | Scientific Literature | |
8. | ALA4325800 | Binding | Inhibition of human placenta CatD at 50 nM using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and measured by FRET assay | Homo sapiens | 31 | ALA4321885 | assay format | Scientific Literature | |
9. | ALA4325801 | Binding | Inhibition of Ixodes ricinus CatD expressed in Escherichia coli BL21(DE3) at 50 nM using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and measured by FRET assay | Ixodes ricinus | 31 | ALA4321885 | assay format | Scientific Literature | |
10. | ALA4325802 | Binding | Inhibition of Baker's yeast proteinase A at 50 nM using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and measured by FRET assay | Saccharomyces cerevisiae | 31 | ALA4321885 | single protein format | Scientific Literature | |
11. | ALA4325803 | ADME | Stability of the compound assessed as papaya papain-mediated compound hydrolysis at 25 ug measured after 18 hrs by HPLC analysis | Carica papaya | 2 | ALA4321885 | single protein format | Scientific Literature | |
12. | ALA4325804 | ADME | Stability of the compound assessed as bovine trypsin-mediated compound hydrolysis at 25 ug measured after 18 hrs by HPLC analysis | Bos taurus | 2 | ALA4321885 | assay format | Scientific Literature | |
13. | ALA4325805 | ADME | Stability of the compound assessed as bovine chymotrypsin-mediated compound hydrolysis at 25 ug measured after 18 hrs by HPLC analysis | Bos taurus | 2 | ALA4321885 | assay format | Scientific Literature | |
14. | ALA4325806 | ADME | Stability of the compound assessed as Geobacillus stearothermophilus thermolysin-mediated compound hydrolysis at 25 ug measured after 18 hrs by HPLC analysis | Geobacillus stearothermophilus | 2 | ALA4321885 | single protein format | Scientific Literature | |
15. | ALA4325807 | Binding | Inhibition of papaya papain at 1 uM using Z-Phe-Arg-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins by fluorescence assay | Carica papaya | 2 | ALA4321885 | single protein format | Scientific Literature | |
16. | ALA4325808 | Binding | Inhibition of bovine trypsin at 1 uM using Z-Phe-Arg-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins by fluorescence assay | Bos taurus | 2 | ALA4321885 | assay format | Scientific Literature | |
17. | ALA4325809 | Binding | Inhibition of bovine chymotrypsin at 1 uM using Z-Phe-Arg-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins by fluorescence assay | Bos taurus | 2 | ALA4321885 | assay format | Scientific Literature | |
18. | ALA4325810 | Binding | Inhibition of Geobacillus stearothermophilus thermolysin at 1 uM using Abz-Ala-Gly-Leu-Ala-nitro-benzylamide as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins by fluorescence assay | Geobacillus stearothermophilus | 2 | ALA4321885 | single protein format | Scientific Literature | |
19. | ALA4325811 | Binding | Inhibition of recombinant human N-terminal FLAG-tagged renin (67 to 406 residues) expressed in HEK cells at 5 uM using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(Dabcyl)-Arg as substrate preincubated for 10 mins followed by substrate addition and measured by FRET assay | Homo sapiens | 31 | ALA4321885 | cell-based format | Scientific Literature | |
20. | ALA4325812 | Binding | Inhibition of recombinant human C-terminal 10His-tagged BACE1 expressed in mouse NS0 cells at 5 uM using Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg as substrate preincubated for 10 mins followed by substrate addition and measured by FRET assay | Homo sapiens | 31 | ALA4321885 | cell-based format | Scientific Literature |