| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4359561 | B | Selectivity ratio of IC50 for nanoluciferase-tagged AIMP2 (unknown origin) expressed in human A549 cells to IC50 for nanoluciferase-tagged AIMP2 DX2 isoform (unknown origin) expressed in human A549 cells | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 2. | ALA4359562 | F | Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay | Homo sapiens | 3 | ALA4354880 | cell-based format | Scientific Literature | |
| 3. | ALA4359563 | A | Inhibition of nanoluciferase-tagged AIMP2 (unknown origin) expressed in human A549 cells measured after 4 hrs by luminescence assay | Homo sapiens | 3 | ALA4354880 | cell-based format | Scientific Literature | |
| 4. | ALA4359564 | B | Inhibition of nanoluciferase-tagged AIMP2 DX2 isoform (unknown origin) expressed in human A549 cells measured after 4 hrs by luminescence assay | Homo sapiens | 3 | ALA4354880 | cell-based format | Scientific Literature | |
| 5. | ALA4359565 | B | Inhibition of nanoluciferase-tagged AIMP2 DX2 isoform (unknown origin) expressed in human A549 cells at 40 uM measured after 4 hrs by luminescence assay relative to control | Homo sapiens | 39 | ALA4354880 | cell-based format | Scientific Literature | |
| 6. | ALA4359566 | A | Cytotoxicity against human WI26 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 3 | ALA4354880 | cell-based format | Scientific Literature | |
| 7. | ALA4359567 | B | Binding affinity to AIMP2 D2X isoform (unknown origin) by fluorescence-based equilibrium binding assay | Homo sapiens | 1 | ALA4354880 | single protein format | Scientific Literature | |
| 8. | ALA4359568 | B | Inhibition of FLAG-tagged AIMP2 DX2 isoform D52A mutant (unknown origin) expressed in 293T cells assessed as reduction in HSP90 protein interaction measured after 4 hrs by immunoprecipitation assay | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 9. | ALA4359569 | B | Inhibition of FLAG-tagged AIMP2 DX2 isoform T82A mutant (unknown origin) expressed in 293T cells assessed as reduction in HSP90 protein interaction measured after 4 hrs by immunoprecipitation assay | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 10. | ALA4359570 | B | Inhibition of FLAG-tagged AIMP2 DX2 isoform D52A mutant (unknown origin) expressed in 293T cells assessed as reduction in HSP90 protein interaction by measuring increase in DX2 degradation measured after 12 hrs by immunoblotting assay | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 11. | ALA4359571 | B | Inhibition of FLAG-tagged AIMP2 DX2 isoform T82A mutant (unknown origin) expressed in 293T cells assessed as reduction in HSP90 protein interaction by measuring increase in DX2 degradation measured after 12 hrs by immunoblotting assay | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 12. | ALA4359572 | B | Induction of AIMP2 DX2 isoform degradation in human H460 cells measured after 12 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354880 | cell-based format | Scientific Literature | |
| 13. | ALA4359573 | A | Induction of AIMP2 degradation in human H460 cells up to 5 uM measured after 12 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354880 | cell-based format | Scientific Literature | |
| 14. | ALA4359574 | B | Induction of AIMP2 DX2 isoform degradation in human H460 cells assessed as reduction in AIMP2 DX2 mRNA level up to 5 uM measured after 12 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 15. | ALA4359575 | B | Induction of AIMP2 DX2 isoform in human H460 cells assessed as induction of Siah1-mediated AIMP2 DX2 ubiquitination at 1.2 uM measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 16. | ALA4359576 | B | Inhibition of His6-tagged AIMP2 DX2 isoform (unknown origin) assessed as reduction in AIMP2 DX2 isoform-HSP90 protein-protein interaction at 1.2 uM measured after 4 hrs by pull down assay | Homo sapiens | 1 | ALA4354880 | single protein format | Scientific Literature | |
| 17. | ALA4359577 | B | Inhibition of LgBiT-tagged AIMP2 DX2 isoform (unknown origin) expressed in human A549 cells harboring SmBiT-tagged HSP90 assessed as reduction in HSP90-AIMP2 DX2 isoform-protein-protein interaction measured after 4 hrs by luminescence assay | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 18. | ALA4359578 | B | Inhibition of LgBiT-tagged PRKACA-SmBiT-tagged PRKAR2A (unknown origin) protein-protein interaction expressed in human A549 cells at 5 uM measured after 4 hrs by luminescence assay | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 19. | ALA4359579 | B | Inhibition of AIMP2 DX2 isoform in human H460 cells assessed as reduction in AIMP2 DX2 isoform-HSP90 protein-protein interaction up to 5 uM measured after 4 hrs by immunoprecipitation assay | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature | |
| 20. | ALA4359580 | B | Binding affinity to AIMP2 DX2 isoform in human H460 cells assessed as increase in AIMP2 DX2 isoform-Siah1 protein-protein interaction by measuring up to 5 uM measured after 4 hrs by immunoprecipitation assay | Homo sapiens | 1 | ALA4354880 | cell-based format | Scientific Literature |
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