# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4386414 | B | Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method | Homo sapiens | 6 | ALA4385611 | cell-based format | Scientific Literature | |
2. | ALA4386415 | B | Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method | Homo sapiens | 6 | ALA4385611 | cell-based format | Scientific Literature | |
3. | ALA4386416 | B | Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method | Homo sapiens | 6 | ALA4385611 | cell-based format | Scientific Literature | |
4. | ALA4386417 | F | Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA | Homo sapiens | 6 | ALA4385611 | cell-based format | Scientific Literature | |
5. | ALA4386418 | F | Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA | Homo sapiens | 6 | ALA4385611 | cell-based format | Scientific Literature | |
6. | ALA4386419 | F | Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay | Homo sapiens | 6 | ALA4385611 | cell-based format | Scientific Literature | |
7. | ALA4386420 | F | Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay | Homo sapiens | 6 | ALA4385611 | cell-based format | Scientific Literature | |
8. | ALA4386421 | P | Aqueous solubility of the compound in pH 7.4 phosphate-buffered saline at 200 uM after 24 hrs by shake-flask method | 2 | ALA4385611 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4386422 | P | n-Octanol-PBS buffer partition coefficient, log D of the compound at 100 uM at pH 7.4 after 1 hr by LC-MS/MS analysis | 2 | ALA4385611 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4386423 | P | Chemical stability in PBS buffer at pH 7.4 assessed as compound recovery at 4 degC | 2 | ALA4385611 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4386424 | A | Protein binding in human plasma at 10 uM after 4 hrs by HPLC-MS/MS-based equilibrium dialysis method | Homo sapiens | 2 | ALA4385611 | cell-free format | Scientific Literature | |
12. | ALA4386425 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 5 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4385611 | cell-based format | Scientific Literature | |
13. | ALA4386426 | A | Apparent permeability across apical to basolateral side in human Caco2 cells assessed as drug recovery at 5 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4385611 | cell-based format | Scientific Literature | |
14. | ALA4386427 | A | Apparent permeability across basolateral to apical side in human Caco2 cells at 5 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4385611 | cell-based format | Scientific Literature | |
15. | ALA4386428 | A | Apparent permeability across basolateral to apical side in human Caco2 cells assessed as drug recovery at 5 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4385611 | cell-based format | Scientific Literature | |
16. | ALA4386429 | A | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in human Caco2 cells at 5 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4385611 | cell-based format | Scientific Literature | |
17. | ALA4386430 | A | Apparent permeability across apical to basolateral side in MDCK-MDR1 cells 120 mins by LC-MS/MS analysis | Canis lupus familiaris | 2 | ALA4385611 | cell-based format | Scientific Literature | |
18. | ALA4386431 | A | Apparent permeability across apical to basolateral side in MDCK-MDR1 cells assessed as drug recovery | Canis lupus familiaris | 2 | ALA4385611 | cell-based format | Scientific Literature | |
19. | ALA4386432 | A | Apparent permeability across basolateral to apical side in MDCK-MDR1 cells 120 mins by LC-MS/MS analysis | Canis lupus familiaris | 2 | ALA4385611 | cell-based format | Scientific Literature | |
20. | ALA4386433 | A | Apparent permeability across basolateral to apical side in MDCK-MDR1 cells assessed as drug recovery | Canis lupus familiaris | 2 | ALA4385611 | cell-based format | Scientific Literature |