| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4394427 | F | Antiproliferative activity against human PC3 cells measured after 72 hrs by celltiter-glo assay | Homo sapiens | 7 | ALA4393668 | cell-based format | Scientific Literature | |
| 2. | ALA4394428 | F | Antiproliferative activity against human DU145 cells measured after 72 hrs by celltiter-glo assay | Homo sapiens | 7 | ALA4393668 | cell-based format | Scientific Literature | |
| 3. | ALA4394429 | F | Antiproliferative activity against human C4-2B cells measured after 96 hrs by celltiter-glo assay | Homo sapiens | 7 | ALA4393668 | cell-based format | Scientific Literature | |
| 4. | ALA4394430 | B | Inverse agonist activity at Gal4-fused RORgamma LBD (unknown origin) expressed in 293T cells measured after 24 hrs by dual-luciferase reporter gene assay | Homo sapiens | 26 | ALA4393668 | cell-based format | Scientific Literature | |
| 5. | ALA4394432 | B | Binding affinity to human N-terminal His6-tagged RORgamma (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) assessed as change in melting temperature at 200 uM by SYPRO orange-dye based fluorescence assay | Homo sapiens | 26 | ALA4393668 | assay format | Scientific Literature | |
| 6. | ALA4394433 | B | Inverse agonist activity at Gal4-fused RORalpha LBD (unknown origin) expressed in 293T cells measured after 24 hrs by dual-luciferase reporter gene assay | Homo sapiens | 6 | ALA4393668 | cell-based format | Scientific Literature | |
| 7. | ALA4394434 | B | Inverse agonist activity at Gal4-fused RORbeta LBD (unknown origin) expressed in 293T cells measured after 24 hrs by dual-luciferase reporter gene assay | Homo sapiens | 6 | ALA4393668 | cell-based format | Scientific Literature | |
| 8. | ALA4394435 | B | Inverse agonist activity at Gal4-fused LXRalpha LBD (unknown origin) expressed in 293T cells measured after 24 hrs by dual-luciferase reporter gene assay | Homo sapiens | 5 | ALA4393668 | cell-based format | Scientific Literature | |
| 9. | ALA4394436 | B | Inverse agonist activity at Gal4-fused FXR LBD (unknown origin) expressed in 293T cells measured after 24 hrs by dual-luciferase reporter gene assay | Homo sapiens | 5 | ALA4393668 | cell-based format | Scientific Literature | |
| 10. | ALA4394441 | B | Inverse agonist activity at human N-terminal His6-tagged RORgamma (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition of biotinylated co-activator SRC1-4 peptide recruitment by alphascreen assay | Homo sapiens | 5 | ALA4393668 | assay format | Scientific Literature | |
| 11. | ALA4394442 | B | Binding affinity to human N-terminal His6-tagged RORgamma (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry | Homo sapiens | 3 | ALA4393668 | assay format | Scientific Literature | |
| 12. | ALA4394443 | F | Antiproliferative activity against human LNCAP cells measured after 96 hrs by celltiter-glo assay | Homo sapiens | 7 | ALA4393668 | cell-based format | Scientific Literature | |
| 13. | ALA4394444 | F | Antiproliferative activity against human 22Rv1 cells measured after 96 hrs by celltiter-glo assay | Homo sapiens | 7 | ALA4393668 | cell-based format | Scientific Literature | |
| 14. | ALA4394452 | B | Inverse agonist activity at RORgamma in human LNCAP cells harboring PSA reporter gene assessed as inhibition of PSA promoter-driven transcriptional activity after 24 hrs by dual-luciferase reporter gene assay | Homo sapiens | 2 | ALA4393668 | cell-based format | Scientific Literature | |
| 15. | ALA4394453 | B | Inverse agonist activity at RORgamma in human 22Rv1 cells assessed as down regulation of full-length AR expression at 2 to 32 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 2 | ALA4393668 | cell-based format | Scientific Literature | |
| 16. | ALA4394454 | B | Inverse agonist activity at RORgamma in human 22Rv1 cells assessed as down regulation of AR mutant expression at 2 to 32 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 2 | ALA4393668 | cell-based format | Scientific Literature | |
| 17. | ALA4394455 | A | Stability in rat liver microsomes assessed as parent compound remaining at 10 uM measured after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4393668 | microsome format | Scientific Literature | |
| 18. | ALA4394456 | A | Cmax in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA4393668 | organism-based format | Scientific Literature | |
| 19. | ALA4394457 | A | Tmax in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA4393668 | organism-based format | Scientific Literature | |
| 20. | ALA4394458 | A | AUC (0 to t) in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA4393668 | organism-based format | Scientific Literature |
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