| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4414331 | B | Activation of human Gal4-fused RXRalpha LBD transfected in HEK293T after 14 to 16 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 2. | ALA4414332 | B | Activation of human Gal4-fused RXRbeta LBD transfected in HEK293T after 14 to 16 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 3. | ALA4414333 | B | Activation of human Gal4-fused RXRgamma LBD transfected in HEK293T after 14 to 16 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 22 | assay format | Scientific Literature | ||
| 4. | ALA4414334 | B | Activation of human Gal4-fused RXRalpha LBD transfected in HEK293T at 1 uM after 14 to 16 hrs by dual-glo luciferase reporter gene assay relative to bexarotene | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 5. | ALA4414335 | B | Activation of human Gal4-fused RXRbeta LBD transfected in HEK293T at 1 uM after 14 to 16 hrs by dual-glo luciferase reporter gene assay relative to bexarotene | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 6. | ALA4414336 | B | Activation of human Gal4-fused RXRgamma LBD transfected in HEK293T at 1 uM after 14 to 16 hrs by dual-glo luciferase reporter gene assay relative to bexarotene | Homo sapiens | 25 | assay format | Scientific Literature | ||
| 7. | ALA4414337 | B | Activation of human Gal4-fused PPARalpha LBD transfected in HEK293T at 1 uM after 14 to 16 hrs by dual-glo luciferase reporter gene assay relative to GW7647 | Homo sapiens | 25 | assay format | Scientific Literature | ||
| 8. | ALA4414339 | B | Activation of human Gal4-fused PPARgamma LBD transfected in HEK293T at 1 uM after 14 to 16 hrs by dual-glo luciferase reporter gene assay relative to rosiglitazone | Homo sapiens | 25 | assay format | Scientific Literature | ||
| 9. | ALA4414341 | B | Activation of human Gal4-fused PPARdelta LBD transfected in HEK293T at 1 uM after 14 to 16 hrs by dual-glo luciferase reporter gene assay relative to L165,041 | Homo sapiens | 17 | assay format | Scientific Literature | ||
| 10. | ALA4414344 | A | Cytotoxicity against human HepG2 cells up to 50 uM after 48 hrs by WST1 assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 11. | ALA4414345 | P | Aqueous solubility of the compound in distilled water after 24 hrs by HPLC analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA4414347 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as remaining parent compound level at 10 uM preincubated for 5 mins with NADPH generating system followed by liver microsomes addition and measured after 60 mins by HPLC analysis | Rattus norvegicus | 4 | microsome format | Scientific Literature | ||
| 13. | ALA4414348 | B | Binding affinity to recombinant RXRalpha (unknown origin) by isothermal titration calorimetry | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 14. | ALA4414349 | B | Binding affinity to recombinant PPARgamma (unknown origin) by isothermal titration calorimetry | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 15. | ALA4414355 | B | Activation of RXR in human HepG2 cells assessed as increase in ApoE mRNA expression at 1 uM after 12 hrs followed by renewal of medium containing test compounds after 6 hrs by PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4414356 | A | Activation of LXR in human HepG2 cells assessed as increase in SREBP-1c mRNA expression at 1 uM after 12 hrs followed by renewal of medium containing test compounds after 6 hrs by PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4414358 | B | Activity at LXR in human HepG2 cells assessed as reduction in T0901317-induced activation of SREBP-1c mRNA expression at 1 uM after 12 hrs followed by renewal of medium containing test compounds after 6 hrs by PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4414359 | B | Antagonist activity at human Gal4-fused LXRalpha expressed in HEK293T cells assessed as inhibition of T0901317 induced response at 1 uM after 14 to 16 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4414360 | A | Drug uptake in C57BL6/JRj mouse plasma at 10 mg/kg, po administered as single dose and measured after 2 hrs by LS-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4414361 | A | Drug uptake in C57BL6/JRj mouse liver at 10 mg/kg, po administered as single dose and measured after 2 hrs by LS-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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