# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4354695 | B | Competitive substrate activity at ABCG2 (unknown origin) expressed in High Five insect cell vesicle membrane assessed as stimulation of ATPase activity at 0.75 uM by PREDEASY ATPase assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
2. | ALA4354697 | B | Reversal of ABCG2 482-T7 mutant (unknown origin) expressed in HEK293 cells-mediated multidrug resistance assessed as potentiation of mitoxantrone-induced cytotoxicity at 2.5 to 5 uM pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA4354698 | B | Reversal of ABCG2 482-G2 mutant (unknown origin) expressed in HEK293 cells-mediated multidrug resistance assessed as potentiation of mitoxantrone-induced cytotoxicity at 2.5 to 5 uM pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
4. | ALA4354699 | B | Reversal of ABCG2 (unknown origin) expressed in HEK293 cells-mediated multidrug resistance assessed as potentiation of mitoxantrone-induced cytotoxicity at 2.5 to 5 uM pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4354700 | B | Reversal of ABCG2-mediated multidrug resistance in human S1-M1-80 cells assessed as potentiation of doxorubicin-induced cytotoxicity at 5 uM pretreated with compound for 2 hrs followed by doxorubicin challenge for 44 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4354701 | B | Reversal of ABCG2-mediated multidrug resistance in human S1-M1-80 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 5 uM pretreated with compound for 2 hrs followed by mitoxantrone challenge for 44 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4354702 | B | Reversal of ABCG2-mediated multidrug resistance in human NCI-H460/MX20 cells assessed as cisplatin-induced cytotoxicity at 5 uM pretreated with compound for 2 hrs followed by cisplatin challenge for 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4354703 | B | Reversal of ABCG2-mediated multidrug resistance in human NCI-H460/MX20 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 2.5 to 5 uM pretreated with compound for 2 hrs followed by mitoxantrone challenge for 44 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4354704 | A | Cytotoxicity against human NCI-H460 cells assessed as concentration that causes inhibition of cell viability by <=20% incubated for 24 hrs by MTT assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
10. | ALA4354705 | A | Cytotoxicity against human NCI-H460/MX20 cells assessed as concentration that causes inhibition of cell viability by <=20% incubated for 24 hrs by MTT assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
11. | ALA4354706 | B | Reversal of ABCG2-mediated multidrug resistance in human NCI-H460/MX20 cells assessed as potentiation of mitoxantrone-induced cytotoxicity by measuring inhibition of cell proliferation at 10 uM pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay (Rvb = 24 +/- 3%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
12. | ALA4354710 | B | Reversal of ABCG2-mediated multidrug resistance in human NCI-H460/MX20 cells assessed as potentiation of mitoxantrone-induced cytotoxicity by measuring inhibition of cell proliferation pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
13. | ALA4354711 | A | Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA4354712 | A | Cytotoxicity against human NCI-H460/MX20 cells assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA4354713 | A | Cytotoxicity against human S1 cells assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA4354714 | A | Cytotoxicity against human S1-M1-80 cells assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA4354715 | A | Cytotoxicity against HEK293 cells transfected with pcDNA3.1 assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA4354716 | A | Cytotoxicity against HEK293 cells expressing wild type ABCG2-482-R2 assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA4354717 | A | Cytotoxicity against HEK293 cells harbouring ABCG2-482-G2 mutant assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA4354718 | A | Cytotoxicity against HEK293 cells harbouring ABCG2-482-T7 mutant assessed as inhibition of cell viability at 5 to 25 uM incubated for 2 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature |