# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4395491 | B | Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay | Homo sapiens | 15 | ALA4393698 | cell-based format | Scientific Literature | |
2. | ALA4395492 | B | Inhibition of GCase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay relative to control | Homo sapiens | 15 | ALA4393698 | cell-based format | Scientific Literature | |
3. | ALA4395493 | B | Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay | Homo sapiens | 15 | ALA4393698 | cell-based format | Scientific Literature | |
4. | ALA4395494 | B | Inhibition of NLGase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay relative to control | Homo sapiens | 15 | ALA4393698 | cell-based format | Scientific Literature | |
5. | ALA4395495 | F | Anti-inflammatory activity in human CuFi1 cells assessed as reduction in Pseudomonas aeruginosa PAO1-induced IL-8 mRNA expression level at 0.1 uM pretreated for 1 hr followed by Pseudomonas aeruginosa PAO1 challenge and measured after 4 hrs by RT-PCR analysis relative to control | Homo sapiens | 7 | ALA4393698 | cell-based format | Scientific Literature | |
6. | ALA4395496 | F | Anti-inflammatory activity in human CuFi1 cells assessed as reduction in Pseudomonas aeruginosa PAO1-induced IL-8 mRNA expression level pretreated for 1 hr followed by Pseudomonas aeruginosa PAO1 challenge and measured after 4 hrs by RT-PCR analysis | Homo sapiens | 5 | ALA4393698 | cell-based format | Scientific Literature | |
7. | ALA4395497 | F | Anti-inflammatory activity in human CuFi1 cells assessed as reduction in Pseudomonas aeruginosa PAO1-induced IL-8 mRNA expression level pretreated for 1 hr followed by Pseudomonas aeruginosa PAO1 challenge and measured after 4 hrs by RT-PCR analysis relative to control | Homo sapiens | 4 | ALA4393698 | cell-based format | Scientific Literature | |
8. | ALA4395498 | F | Anti-inflammatory activity in human Bronchial epithelial cells assessed as reduction in Pseudomonas aeruginosa PAO1-induced IL-8 mRNA expression level at 10 nM pretreated for 1 hr followed by Pseudomonas aeruginosa PAO1 challenge and measured after 4 hrs by RT-PCR analysis relative to control | Homo sapiens | 2 | ALA4393698 | assay format | Scientific Literature | |
9. | ALA4395499 | A | Induction of apoptosis in human CuFi1 cells incubated for 48 hrs by Muse Annexin V based cell counter assay | Homo sapiens | 9 | ALA4393698 | cell-based format | Scientific Literature | |
10. | ALA4395500 | A | Cytotoxicity against human CuFi1 cells assessed as reduction in cell viability incubated for 48 hrs by Muse cell analyser method | Homo sapiens | 9 | ALA4393698 | cell-based format | Scientific Literature |