#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4416606	Functional	Inhibition of LPS-induced serum IL-1beta production in C57BL/6 mouse at 10 mg/kg, ip pretreated before LPS challenge and measured after 2.5 hrs post LPS challenge by ELISA	Mus musculus	3	ALA4414625	organism-based format	Scientific Literature
2.	ALA4416607	Functional	Inhibition of LPS-induced serum TNFalpha production in C57BL/6 mouse at 10 mg/kg, ip pretreated before LPS challenge and measured after 2.5 hrs post LPS challenge by ELISA	Mus musculus	2	ALA4414625	organism-based format	Scientific Literature
3.	ALA4416608	Binding	Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA	Mus musculus	27	ALA4414625	cell-based format	Scientific Literature
4.	ALA4416609	Binding	Inhibition of NLRP3 in mouse peritoneal macrophages assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA	Mus musculus	3	ALA4414625	single protein format	Scientific Literature
5.	ALA4416610	Binding	Inhibition of NLRC4 in mouse J774A.1 cells assessed as inhibition of LPS and poly(dA:dT)-induced IL-1beta production incubated with LPS for 1 hr followed by poly(dA:dT) addition and further incubated for 8 hrs ELISA	Mus musculus	2	ALA4414625	cell-based format	Scientific Literature
6.	ALA4416611	Binding	Ratio of IC50 for inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA to IC50 for inhibition of NLRP3 in mouse peritoneal macrophages assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA	Mus musculus	1	ALA4414625	cell-based format	Scientific Literature
7.	ALA4416612	Binding	Inhibition of AIM2 in mouse J774A.1 cells assessed as inhibition of LPS and flagellin-induced IL-1beta production incubated with LPS for 1 hr followed by flagellin addition and further incubated for 6 hrs ELISA	Mus musculus	2	ALA4414625	cell-based format	Scientific Literature
8.	ALA4416613	Functional	Inhibition of LPS-induced serum IL-1beta production in nlrp3-/- C57BL/6 mouse at 10 mg/kg, ip pretreated before LPS challenge and measured after 2.5 hrs post LPS challenge by ELISA	Mus musculus	1	ALA4414625	organism-based format	Scientific Literature
9.	ALA4416614	Toxicity	Toxicity in human hCMEC/D3 cells assessed as reduction in cell viability at 20 uM	Homo sapiens	1	ALA4414625	cell-based format	Scientific Literature
10.	ALA4416615	ADME	Apparent permeability in apical to basolateral side in human hCMEC/D3 cells at 20 uM incubated up to 60 mins by HPLC analysis	Homo sapiens	1	ALA4414625	cell-based format	Scientific Literature
11.	ALA4416616	ADME	Apparent permeability in basolateral to apical side in human hCMEC/D3 cells at 20 uM incubated up to 60 mins by HPLC analysis	Homo sapiens	1	ALA4414625	cell-based format	Scientific Literature
12.	ALA4416617	ADME	Efflux ratio in human hCMEC/D3 cells at 20 uM incubated up to 60 mins by HPLC analysis	Homo sapiens	1	ALA4414625	cell-based format	Scientific Literature
13.	ALA4416618	ADME	Drug level in C57BL/6 mouse brain at 20 mg/kg, po measured after 0.5 hrs by LC-MS/MS analysis	Mus musculus	1	ALA4414625	organism-based format	Scientific Literature
14.	ALA4416619	ADME	Drug level in C57BL/6 mouse brain at 20 mg/kg, po measured after 1 hr by LC-MS/MS analysis	Mus musculus	1	ALA4414625	organism-based format	Scientific Literature
15.	ALA4416620	ADME	Drug level in C57BL/6 mouse brain at 20 mg/kg, po measured after 4 hrs by LC-MS/MS analysis	Mus musculus	1	ALA4414625	organism-based format	Scientific Literature
16.	ALA4416621	ADME	Drug level in C57BL/6 mouse plasma at 20 mg/kg, po measured after 0.5 hrs by LC-MS/MS analysis	Mus musculus	1	ALA4414625	organism-based format	Scientific Literature
17.	ALA4416622	ADME	Drug level in C57BL/6 mouse plasma at 20 mg/kg, po measured after 1 hr by LC-MS/MS analysis	Mus musculus	1	ALA4414625	organism-based format	Scientific Literature
18.	ALA4416623	ADME	Drug level in C57BL/6 mouse plasma at 20 mg/kg, po measured after 4 hrs by LC-MS/MS analysis	Mus musculus	1	ALA4414625	organism-based format	Scientific Literature
19.	ALA4416624	ADME	Ratio of drug level in brain to plasma of C57BL/6 mouse at 20 mg/kg, po measured after 0.5 hrs by LC-MS/MS analysis	Mus musculus	1	ALA4414625	organism-based format	Scientific Literature
20.	ALA4416625	ADME	Ratio of drug level in brain to plasma of C57BL/6 mouse at 20 mg/kg, po measured after 1 hr by LC-MS/MS analysis	Mus musculus	1	ALA4414625	organism-based format	Scientific Literature