| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4391164 | B | Inhibition of human recombinant AChE using ATCh as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by Ellman method | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 2. | ALA4391165 | B | Inhibition of human serum BChE using BTCh as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by Ellman's method | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 3. | ALA4391166 | B | Selectivity index, ratio of IC50 for human serum BChE to IC50 for human recombinant AChE | Homo sapiens | 9 | protein format | Scientific Literature | ||
| 4. | ALA4391167 | B | Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillation counting assay | Sus scrofa | 24 | assay format | Scientific Literature | ||
| 5. | ALA4391168 | B | Inhibition of human recombinant CDK5/p25 using histone H1 as substrate in presence of [gamma-33P]ATP incubated for 30 mins by liquid scintillation counting assay | Homo sapiens | 24 | protein complex format | Scientific Literature | ||
| 6. | ALA4391169 | A | Cytotoxicity against human HuH7 cells assessed as growth inhibition incubated for 48 hrs by Hoechst 33342 staining based assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 7. | ALA4391170 | A | Cytotoxicity against human Caco2 cells assessed as growth inhibition incubated for 48 hrs by Hoechst 33342 staining based assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 8. | ALA4391171 | A | Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by Hoechst 33342 staining based assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 9. | ALA4391172 | A | Cytotoxicity against human HCT116 cells assessed as growth inhibition incubated for 48 hrs by Hoechst 33342 staining based assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 10. | ALA4391173 | A | Cytotoxicity against human PC3 cells assessed as growth inhibition incubated for 48 hrs by Hoechst 33342 staining based assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 11. | ALA4391174 | A | Cytotoxicity against human NCI-H727 cells assessed as growth inhibition incubated for 48 hrs by Hoechst 33342 staining based assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 12. | ALA4391175 | A | Cytotoxicity against human HaCaT cells assessed as growth inhibition incubated for 48 hrs by Hoechst 33342 staining based assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 13. | ALA4391176 | A | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability at 100 uM incubated for 24 hrs by MTT assay relative to untreated cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4391177 | A | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4391178 | A | Cytotoxicity against MDCK2-MDR1 cells assessed as reduction in cell viability at 75 uM incubated for 2 hrs by MTT assay | Canis lupus familiaris | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4391179 | A | Apparent permeability across apical to basolateral side in MDCK2-MDR1 cells by HPLC analysis | Canis lupus familiaris | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA4391180 | A | Apparent permeability across basolateral to apical side in MDCK2-MDR1 cells by HPLC analysis | Canis lupus familiaris | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA4391181 | A | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in MDCK2-MDR1 cells by HPLC analysis | Canis lupus familiaris | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA4391182 | B | Binding affinity to human wild-type AAK1 (G25 to L333 residues) expressed in bacterial expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4391183 | B | Binding affinity to human phosphorylated ABL1 E255K mutant (S229 to K512 residues) expressed in mammalian expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature |
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