| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4310245 | F | Anticonvulsive activity in C57BL/6N mouse assessed as protection against 50.2 +/- 1.9 mg/kg pentylenetetrazole-induced seizures by measuring elevation in seizure threshold at 0.3 mg/kg, ip pretreated for 30 mins followed by pentylenetetrazole tail-vein infusion | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4310246 | B | Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current at 30 uM after 5 mins at -70 mV holding potential by two-microelectrode voltage clamp method relative to control | Homo sapiens | 41 | cell-based format | Scientific Literature | ||
| 3. | ALA4310247 | B | Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current at 100 uM after 5 mins at -70 mV holding potential by two-microelectrode voltage clamp method relative to control | Homo sapiens | 41 | cell-based format | Scientific Literature | ||
| 4. | ALA4310248 | B | Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 5. | ALA4310249 | B | Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current up to 100 uM after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 6. | ALA4310250 | A | Positive allosteric modulation of GABA-A alpha1beta1gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA4310251 | A | Positive allosteric modulation of GABA-A alpha1beta1gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current at 300 uM after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4310252 | B | Positive allosteric modulation of GABA-A alpha1beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA4310253 | B | Positive allosteric modulation of GABA-A alpha1beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current at 300 uM after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA4310254 | B | Positive allosteric modulation of GABA-A alpha1beta3(N265S)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current up to 100 uM after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4310255 | B | Positive allosteric modulation of GABA-A alpha1beta3(N265S)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4310256 | A | Positive allosteric modulation of GABA-A alpha1beta1(S290N)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4310257 | A | Positive allosteric modulation of GABA-A alpha1beta1(S290N)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current up to 100 uM after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4310258 | B | Positive allosteric modulation of GABA-A alpha1beta3(F289S)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4310259 | B | Positive allosteric modulation of GABA-A alpha1beta3(F289S)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current up to 100 uM after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4310260 | A | Induction of current in Xenopus laevis oocytes at 10 to 100 uM after 5 mins by two-microelectrode voltage clamp method | Xenopus laevis | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4310261 | B | Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current at 10 to 100 uM co-treated with GABA for 20 secs followed by compound washout and measured after 5 mins at -70 mV holding potential by two-microelectrode voltage clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4310262 | B | Positive allosteric modulation of GABA-A alpha1(M235W)beta3gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current up to 100 uM after 15 mins at -70 mV holding potential by two-microelectrode voltage clamp method relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4310263 | B | Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current at 10 to 100 uM co-treated with GABA-A open-channel blocker picrotoxin measured after 5 mins at -70 mV holding potential by two-microelectrode voltage clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4310264 | B | Positive allosteric modulation of GABA-A receptor in Sprague-Dawley rat primary hippocampal neurons assessed as miniature inhibitory postsynaptic current mean frequency at 10 uM for 300 secs at -70 mV holding potential by patch-clamp method (Rvb = 95 to 112%) | Rattus norvegicus | 2 | protein complex format | Scientific Literature |
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