| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4387131 | ADME | Efflux ratio in MDCK2 expressing mouse bcrp1 | Canis lupus familiaris | 23 | ALA4385643 | cell-based format | Scientific Literature | |
| 2. | ALA4387132 | ADME | Efflux ratio in gMDCKI cells expressing human MDR1 | Canis lupus familiaris | 23 | ALA4385643 | cell-based format | Scientific Literature | |
| 3. | ALA4387133 | Binding | Inhibition of human full length GST-tagged CDK4 (1 to 303(end) amino acids)/Cyclin D3 (1 to 292(end) amino acids) expressed in baculovirus expression system assessed as inhibition constant using Ulight-4E-BP1 as substrate preincubated for 30 mins followed by substrate addition and incubated for 90 mins by TR-FRET assay | Homo sapiens | 20 | ALA4385643 | assay format | Scientific Literature | |
| 4. | ALA4387134 | Binding | Inhibition of human full length GST-tagged CDK6 (1 to 326(end) amino acids)/Cyclin D3 (1 to 292(end) amino acids) expressed in baculovirus expression system assessed as inhibition constant using Ulight-4E-BP1 as substrate preincubated for 30 mins followed by substrate addition and incubated for 90 mins by TR-FRET assay | Homo sapiens | 20 | ALA4385643 | assay format | Scientific Literature | |
| 5. | ALA4387135 | ADME | Inhibition of human recombinant full length GST-tagged CDK1/Cyclin A2 expressed in sf9 insect cells assessed as inhibition constant using Ulight-4E-BP1 as substrate preincubated for 30 mins followed by substrate addition and incubated for 90 mins by TR-FRET assay | Homo sapiens | 20 | ALA4385643 | cell-based format | Scientific Literature | |
| 6. | ALA4387138 | Unassigned | Selectivity ratio of Ki for human recombinant full length GST-tagged CDK1/Cyclin A2 expressed in sf9 insect cells to Ki for human full length GST-tagged CDK6 (1 to 326(end) amino acids)/Cyclin D3 (1 to 292(end) amino acids) expressed in baculovirus expression system | Homo sapiens | 17 | ALA4385643 | cell-based format | Scientific Literature | |
| 7. | ALA4387397 | Physicochemical | Lipophilicity, log D of the compound by microscale shake flask method | 5 | ALA4385643 | small-molecule physicochemical format | Scientific Literature |
The page will load shortly, Thanks for your patience!