# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4361693 | Functional | Cytoprotective activity in human SH-SY5Y cells assessed as increase in HO1 protein level at 20 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4359848 | cell-based format | Scientific Literature | |
2. | ALA4361694 | Functional | Cytoprotective activity in human SH-SY5Y cells assessed as increase in HO1 protein level incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4359848 | cell-based format | Scientific Literature | |
3. | ALA4361695 | Functional | Cytoprotective activity in human SH-SY5Y cells assessed as increase in HO1 mRNA expression level at 10 uM incubated for 6 hrs by RT-PCR analysis relative to control | Homo sapiens | 4 | ALA4359848 | cell-based format | Scientific Literature | |
4. | ALA4361696 | Functional | Cytoprotective activity in human SH-SY5Y cells assessed as increase in Nrf2 mRNA expression level at 10 uM incubated for 6 hrs by RT-PCR analysis | Homo sapiens | 4 | ALA4359848 | cell-based format | Scientific Literature | |
5. | ALA4361697 | Functional | Neuroprotective activity in human SH-SY5Y cells assessed as reduction in H2O2-induced intracellular ROS formation at 10 uM preincubated for 24 hrs followed H2O2 addition and measured after 10 to 90 mins by DCFH-DA staining based assay | Homo sapiens | 4 | ALA4359848 | cell-based format | Scientific Literature | |
6. | ALA4361698 | Functional | Neuroprotective activity in human SH-SY5Y cells assessed as reduction in H2O2-induced intracellular ROS formation at 10 uM and measured for 30 to 300 mins by DCFH-DA staining based assay | Homo sapiens | 4 | ALA4359848 | cell-based format | Scientific Literature | |
7. | ALA4361699 | ADME | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability up to 20 uM incubated for 24 hrs by MTT assay | Homo sapiens | 4 | ALA4359848 | cell-based format | Scientific Literature | |
8. | ALA4361700 | Binding | Antagonist activity at GluN1a/GluN2A (unknown origin) expressed in Xenopus laevis oocytes at -60 mV holding potential by voltage clamp method | Homo sapiens | 8 | ALA4359848 | cell-based format | Scientific Literature | |
9. | ALA4361701 | ADME | Cytotoxicity against human H4 cells harboring swedish mutant form of APP assessed as reduction in cell viability up to 20 uM incubated for 24 hrs by MTT assay | Homo sapiens | 3 | ALA4359848 | cell-based format | Scientific Literature | |
10. | ALA4361702 | Binding | Inhibition of alpha secretase in human H4 cells harboring swedish mutant form of APP assessed as increase in sAPPalpha protein level at 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA4359848 | cell-based format | Scientific Literature | |
11. | ALA4361703 | ADME | Effect on total intracellular APP in human H4 cells harboring swedish mutant form of APP assessed as change in full length APP protein level at 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4359848 | cell-based format | Scientific Literature | |
12. | ALA5097102 | Binding | Inhibition of GluN1/GluN2B NMDA receptor (unknown origin) expressed in xenopus laevis oocytes with holding potential of -70 mV by two-electrode voltage-clamp assay | Homo sapiens | 1 | ALA5096162 | cell-based format | Scientific Literature |