| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4478442 | F | Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as reduction of virus-induced cytopathic effect at 10 uM after 6 days by MTS assay | Human immunodeficiency virus 1 | 31 | organism-based format | Scientific Literature | ||
| 2. | ALA4478443 | A | Cytotoxicity against human CEM-SS cells assessed as cell viability at 10 uM after 6 days by MTS assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 3. | ALA4478444 | B | Inhibition of HIV1 recombinant integrase expressed in Escherichia coli using [32P]-labeled oligonucleotide as substrate after 60 mins by strand transfer activity assay | Human immunodeficiency virus 1 | 34 | assay format | Scientific Literature | ||
| 4. | ALA4478445 | F | Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as reduction of virus-induced cytopathic effect after 6 days by MTS assay | Human immunodeficiency virus 1 | 9 | organism-based format | Scientific Literature | ||
| 5. | ALA4478446 | A | Cytotoxicity against human CEM-SS cells assessed as cell death after 6 days by MTS assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 6. | ALA4478447 | T | Therapeutic index, ratio of CC50 for human CEM-SS cells to EC50 for HIV1 3B infected in human CEM-SS cells | 9 | cell-based format | Scientific Literature | |||
| 7. | ALA4478448 | F | Antiviral activity against HIV1 infected in human P4R5 cells assessed as reduction of virus replication preincubated with cells for 24 hrs followed by viral infection for 48 hrs by 4-methylumbelliferylgalactoside-based MAGI assay | Human immunodeficiency virus 1 | 10 | organism-based format | Scientific Literature | ||
| 8. | ALA4478453 | B | Inhibition of RNase H activity of full length HIV1 reverse transcriptase using RNA-DNA duplex HTS-1 substrate | Human immunodeficiency virus 1 | 10 | single protein format | Scientific Literature | ||
| 9. | ALA4478454 | P | Aqueous solubility of the compound in DPBS | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 10. | ALA4478455 | P | Half life of the compound in DPBS | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA4478456 | A | Half life in human plasma | Homo sapiens | 5 | cell-free format | Scientific Literature | ||
| 12. | ALA4478457 | A | Half life in mouse plasma | Mus musculus | 5 | cell-free format | Scientific Literature | ||
| 13. | ALA4478458 | A | Plasma protein binding in human | Homo sapiens | 5 | cell-free format | Scientific Literature | ||
| 14. | ALA4478459 | A | Plasma protein binding in mouse | Mus musculus | 5 | cell-free format | Scientific Literature | ||
| 15. | ALA4478460 | A | Intrinsic clearance in human liver microsomes during phase 1 measured per mg of protein | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 16. | ALA4478461 | A | Intrinsic clearance in mouse liver microsomes during phase 1 measured per mg of protein | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 17. | ALA4478462 | A | Intrinsic clearance in human liver microsomes assessed as glucuronidation during phase 2 measured per mg of protein | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 18. | ALA4478463 | A | Intrinsic clearance in mouse liver microsomes assessed as glucuronidation during phase 2 measured per mg of protein | Mus musculus | 5 | microsome format | Scientific Literature |
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