| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4397816 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis | Mus musculus | 5 | ALA4396880 | cell-based format | Scientific Literature | |
| 2. | ALA4397817 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in TRAP activity at 5 uM measured after 3 days by colorimetric assay relative to control | Mus musculus | 37 | ALA4396880 | protein format | Scientific Literature | |
| 3. | ALA4397821 | B | Binding affinity to human RANKL by surface plasmon resonance analysis | Homo sapiens | 7 | ALA4396880 | single protein format | Scientific Literature | |
| 4. | ALA4397823 | A | Cytotoxicity against M-CSF-stimulated C57/BL6 mouse bone marrow macrophages assessed as cell viability at 10 uM measured after 2 days by MTT assay (Rvb = 100%) | Mus musculus | 4 | ALA4396880 | cell-based format | Scientific Literature | |
| 5. | ALA4397824 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis | Mus musculus | 4 | ALA4396880 | cell-based format | Scientific Literature | |
| 6. | ALA4397825 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in nuclei size of F-actin ring formation at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by rhodamine phalloidin/DAPI staining-based microscopic analysis | Mus musculus | 4 | ALA4396880 | protein format | Scientific Literature | |
| 7. | ALA4397826 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in nuclei number of F-actin ring formation at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by rhodamine phalloidin/DAPI staining-based microscopic analysis | Mus musculus | 4 | ALA4396880 | protein format | Scientific Literature |
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