# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4483863 | F | Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent inhibition of light emission compared to control. (Single Point Inhibition, %) | Plasmodium berghei | 9,989 | organism-based format | Winzeler Lab Plasmodium Screening Data | ||
2. | ALA4483864 | F | Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent inhibition of light emission compared to control. (Single Point Inhibition, %) | Homo sapiens | 9,989 | cell-based format | Winzeler Lab Plasmodium Screening Data | ||
3. | ALA5241000 | B | Chaperone activity at GCase N370S GBA mutant in patient derived fibroblast cell using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate assessed as substrate cleavage by measuring concentration required for maximal response incubated for 5 days by fluorescence based assay | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
4. | ALA5241001 | P | Solubility of the compound in PBS | 5 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA5241002 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 4 | microsome format | Scientific Literature | ||
6. | ALA5241003 | A | Corrected flux ratio of permeability in pig LLC-PK1 cells overexpressing MDR1 to pig LLC-PK1 cells | Sus scrofa | 4 | cell-based format | Scientific Literature |